抗Caspase 3 [C33]抗体 | Anti-Caspase 3 [C33] antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

WB analysis of HeLa cells treated with camptothecin (2μM) lysate using GTX59551 Caspase 3 antibody [C33].

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	C33
Isotype	IgG1
Application	WB
Reactivity	Human, Mouse, Rat

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	0.5-4 μg/ml

Not tested in other applications.

Calculated MW	31.61 kDa. ( Note )

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PROPERTIES

Form	Liquid
Buffer	PBS, 50% glycerol, 0.5 mg/ml BSA, 0.01% thimerosal
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Recombinant human Caspase-3
Purification	Purified by affinity chromatography
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	CASP3 , CPP32 , CPP32B , SCA1 , caspase 3 , Caspase 3
Cellular Localization	Cytoplasm
Background	The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
Database	・ Gene ID: 836 CASP3 ・ UniProt: P42574 CASP3

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Salaroglio IC et al. J Exp Clin Cancer Res 2018; 37 (1) : 286 increasing intratumor c/ebp-β lip and nitric oxide levels overcome resistance to * in triple negative breast cancer.	Application : WB Reactivity : Human
Salaroglio IC et al. Mol Cancer Ther 2018; (Epub) carbonic anhydrase xii inhibitors overcome p-glycoprotein-mediated resistance to * in glioblastoma.	Application : WB Reactivity : Human
Pinzon-Daza ML et al. J Cereb Blood Flow Metab 2014; 34 (8) : 1258-69 The cross-talk between canonical and non-canonical Wnt-dependent pathways regulates P-glycoprotein expression in human blood-brain barrier cells.	Application : WB Reactivity : Human

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