抗CDC2 [3E1.1]抗体 | Anti-CDC2 [3E1.1] antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	3E1.1
Isotype	IgG1
Application	WB
Reactivity	Xenopus laevis

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APPLICATION

Application Note

WB: Use at an assay dependent dilution. Predicted molecular weight: 34 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW	35 kDa. ( Note )
Specificity/Sensitivity	3E1.1 reacts strongly with immunoblotted antigen but does not immunoprecipitate native p34cdc2.

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PROPERTIES

Form	Liquid
Buffer	Preservative: None. Constituents: PBS
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Xenopus laevis
Immunogen	C terminal fragment, starting from methionine 85 of Xenopus Cdc2 .
Purification	IgG fraction
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Cyclin-Dependent Kinase 1 S Homeolog , Mpf , Pstair , Cdc-2 , Cdc2 , Cdc2-A , Cdc28A , Cdc2X1.1 , Cdk1-A , Cdk1-B , P34Cdc2 , Xcdc2 , Cdk1.S
Cellular Localization	Nuclear
Background	The cell division control protein (cdc2) kinase is a catalytic subunit of a protein kinase complex, called the M phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In the fission yeast Schizosaccharomyces pombe, the gene Cdc2 is responsible for controlling the transition from G1 phase to the S phase and from the G2 phase to the M phase of the cell cycle. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex that is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase.
Database	・ Gene ID: 380246 ・ UniProt: P35567

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