抗Filaggrin抗体 | Anti-Filaggrin antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

	IHC-P analysis of rat stomach tissue using GTX37695 Filaggrin antibody. Dilution : 2.5μg/ml
	IHC-P analysis of mouse brain tissue using GTX37695 Filaggrin antibody. Dilution : 2.5μg/ml
	IHC-P analysis of mouse brain tissue using GTX37695 Filaggrin antibody. Dilution : 2.5μg/ml

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	IHC-P
Reactivity	Human, Mouse, Rat

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
IHC-P	1:100-500 (based on 0.5 mg/ml)

Not tested in other applications.

Calculated MW	435 kDa. ( Note )

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PROPERTIES

Form	Liquid
Buffer	10 mM PBS, 0.02% sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20º C or below. Avoid multiple freeze-thaw cycles.
Concentration	0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	KLH conjugated synthetic peptide derived from human Filaggrin.
Purification	Purified by antigen-affinity chromatography
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	filaggrin , ATOD2
Background	The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
Database	・ Gene ID: 2312 FLG ・ UniProt: P20930 FLG

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Kim SH et al. Nutrients 2020; 12 (1) Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice through Modulating Immune Balance and Skin Barrier Function.	Reactivity : Mouse
Song C et al. Cell Biol Toxicol 2019; (Epub) Evidence for the critical role of the PI3K signaling pathway in particulate matter-induced dysregulation of the inflammatory mediators COX-2/PGE2 and the associated epithelial barrier protein Filaggrin in the bronchial epithelium.	Reactivity : Human, Mouse
Lee CW et al. Int J Mol Sci 2019; 20 (17) Water-Soluble Fullerenol C60(OH)36 toward Effective Anti-Air Pollution Induced by Urban Particulate Matter in HaCaT Cell.	Reactivity : Human
Kim K.P. et al. Nutrition Research 2018; (Epub) Borage oil restores acidic skin pH by up-regulating the activity or expression of filaggrin and enzymes involved in epidermal lactate, free fatty acid, and acidic free amino acid metabolism in essential fatty acid-deficient Guinea pigs.
Xiong Z et al. J Pathol 2017; (Epub) PAX9 regulates squamous cell differentiation and carcinogenesis in the oro-esophageal epithelium.	Application : IHC-P Reactivity : Mouse

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