抗HIF1 beta抗体 | Anti-HIF1 beta antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

	WB analysis of hypoxic HeLa cell lysate using GTX30109 HIF1 beta antibody.
	IHC-P analysis of human skin tissue using GTX30109 HIF1 beta antibody.
	WB analysis of MCF-7 cell lysate using GTX30109 HIF1 beta antibody.

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, ICC/IF, IHC-P, IP, ChIP assay, Gel supershift assays
Reactivity	Human, Mouse, Rat, Sheep, Bovine, Ferret

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	1:2000
ICC/IF	Assay dependent
IHC-P	1:150
IP	1:10 - 1:500
ChIP assay	1:10 - 1:500
Gel supershift assays	Assay dependent

Not tested in other applications.

Calculated MW	87 kDa. ( Note )
Specificity/Sensitivity	This antibody is specific to HIF1 beta / ARNT. The cross-reactivity of ARNT2 is not determined.

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PROPERTIES

Form	Liquid
Buffer	Serum, 0.02% Sodium Azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Fusion protein to human HIF-1 beta containing amino acids 496-789. [UniProt# P27540]
Purification	Unpurified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	aryl hydrocarbon receptor nuclear translocator , HIF-1-beta , HIF-1beta , HIF1-beta , HIF1B , HIF1BETA , TANGO , bHLHe2
Cellular Localization	Nucleus
Background	The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq]
Database	・ Gene ID: 405 ARNT ・ UniProt: P27540 ARNT

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