抗TLR4 [HTA125] (FITC)抗体 | Anti-TLR4 [HTA125] (FITC) antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

FACS analysis of human peripheral blood monocytes using GTX28378 TLR4 antibody [HTA125] (FITC).

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	HTA125
Isotype	IgG2a
Application	ICC/IF, FACS
Reactivity	Human, Dog, Guinea pig, Pig, Rhesus Monkey

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
ICC/IF	Assay dependent
FACS	Neat
Note : FACS Use 10μl of the suggested working dilution to label 106 cells or 100μl whole blood.

Not tested in other applications.

Calculated MW	96 kDa. ( Note )

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PROPERTIES

Form	Liquid
Buffer	PBS, 0.09% Sodium Azide, 1% BSA
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Protect from light.
Concentration	0.1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Ba/F3 cell line expressing TLR4 (CD284).
Purification	Protein G purified From tissue culture supernatant
Conjugation	Fluorescein isothiocyanate (FITC)
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Toll Like Receptor 4 , Armd10 , Cd284 , Tlr-4 , Toll , Tlr4
Background	The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Database	・ Gene ID: 7099 ・ UniProt: O00206

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Krupa A et al. Am J Respir Cell Mol Biol 2013; 48 (2) : 240-9 Bruton's tyrosine kinase mediates FcγRIIa/Toll-like receptor-4 receptor crosstalk in human neutrophils.	Application : ICC/IF Reactivity : Human

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