抗Bcl-2抗体 | Anti-Bcl-2 antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC-Fr, IP, IHC
Reactivity	Human, Mouse, Rat

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APPLICATION

Application Note

This Bcl-2 antibody is recommended for use in IHC with fresh/frozen sections. It has been tested on paraffin embedded sections but it has not faired well.
For WB:1:200

Calculated MW	26 kDa. ( Note )
Specificity/Sensitivity	Reacts with Bcl-2

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PROPERTIES

Form	Liquid
Buffer	PBS with 0.1% sodium azide and 0.2% gelatin
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration	0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Synthetic peptide (Human) (N terminal).
Purification	IgG fraction
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Bcl2, Apoptosis Regulator , Bcl-2 , Ppp1R50 , Bcl2
Cellular Localization	Endoplasmic reticulum, outer mitochondrial membrane and nuclear membrane.
Background	Bcl-2 family is a key regulator of apoptosis that function to either inhibit or promote cell death. Over expression of members such as Bcl-2 and Bcl-xL inhibit the apoptotic process (1,2). The Bcl-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag-1, for example, has been found to form a heterodimer with Bcl-2 resulting in the enhancement of the anti-apoptotic effect of Bcl-2 (3,4). Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis (6). Bad plays a critical role in the Bax-mediated apoptosis pathway by dimerizing with Bcl-xL, causing the displacement of Bax. The displacement of Bax allows apoptosis to proceed (7). Bcl-xS, a shorter version of Bcl-xL (lacking amino acids 126-188), apparently utilizes a different pathway than Bax to induce cell death. Some research suggests that Bcl-xS uses a novel mechanism for regulating caspase or it may use an alternate cell death effector pathway (8,9).
Database	・ Gene ID: 596 ・ UniProt: P10415

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