抗c-Fos抗体 | Anti-c-Fos antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

GTX27963 staining c-Fos in A431 whole cell lysate (lane A) and HeLa whole cell lysate (lane B)

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC-P, IP, IHC
Reactivity	Human, Mouse, Rat

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APPLICATION

Application Note

For IHC-P: Use at a dilution of 1:100. For IP: Use at an assay dependent dilution. For WB: Use at a dilution of 1:200. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW	41 kDa. ( Note )
Positive Control	A-431 and HeLa lysate
Specificity/Sensitivity	Reacts with c-Fos

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PROPERTIES

Form	Liquid
Buffer	Phosphate-buffered saline containing 0.1% sodium azide and 0.2%gelatin
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration	0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	The immunogen corresponding to a region within amino acids 1 and 50 of human c-Fos.
Purification	Affinity purified with antigen
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Fos Proto-Oncogene, Ap-1 Transcription Factor Subunit , Ap-1 , C-Fos , P55 , Fos
Background	The products of the proto-oncogenes c-Jun (c-Jun was previously known as the Fos-binding protein p39) and c-Fos are known to form a complex in the nucleus (2, 6). AP-1 (activating protein-1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common DNA site, the AP-1-binding site (1). There is evidence that AP-1 proteins, mostly those that belong to the Jun group, control cell life and death through their ability to regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16 (3). The Fos and Jun proto-oncogenes expression is induced transiently by a great variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons (5). Studies have established a unique role for Fos in determining the differentiation and activity of progenitors of the osteoclast lineage (4).
Database	・ Gene ID: 2353 ・ UniProt: P01100

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Yajima H et al. Neurobiology of Aging 2018; 64 : 139-146 Early-life-stress induces cognitive disorder in middle-aged mice.	Application : IHC-P Reactivity : Mouse
Trollmann R et al. Am J Physiol Regul Integr Comp Physiol 2010; 299 (6) : R1489-99 Late-gestational systemic hypoxia leads to a similar early gene response in mouse placenta and developing brain.	Application : IHC-P Reactivity : Mouse

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