抗Cyclin E抗体 | Anti-Cyclin E antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC
Reactivity	Human, Mouse, Rat

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APPLICATION

Application Note

For IHC-Fr: Use at an assay dependent dilution. For IP: Use at an an assay dependent dilution. For WB: Use at a dilution of 1:200. Optimal dilutions/concentrations should be determined by the researcher.

Positive Control	KNRK, Jurkat, and K-562

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PROPERTIES

Form	Liquid
Buffer	Phosphate-buffered saline containing 0.1% sodium azide and 0.2% gelatin
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration	0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Rat
Immunogen	Peptide mapping to the carboxy terminus of rat cyclin E
Purification	Purified IgG
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	CCNE1, CCNE, P24864, CYCLE, 898, 123837, Cyclin E, 25729
Cellular Localization	Nuclear
Background	During each cell cycle cyclins undergo periodic accumulation and destruction. As key regulators of the cell cycle the cyclins control important transitions by activating Cdks (1,2). Early in the G1 phase of the cell cycle cyclin D1 induction is followed by cyclin E induction (3,4). This sequential progression is marked early on in G1by the activation of Cdk4 and in mid to late G1 by the activation of Cdk2 and the hyperphosphorylation of pRB (3,5). The final transition into S phase is thought to be dependent on the increased expression and association of cyclin E and Cdk2 (5,6).

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Wu CH et al. Int J Mol Sci 2018; 19 (3) Suppression of Cell Growth, Migration and Drug Resistance by Ethanolic Extract of Antrodia cinnamomea in Human Lung Cancer A549 Cells and C57BL/6J Allograft Tumor Model.	Application : WB Reactivity : Human
Liu FC et al. Phytomedicine 2013; 20 (10) : 874-82 Elucidating the inhibitory mechanisms of the ethanolic extract of the fruiting body of the mushroom Antrodia cinnamomea on the proliferation and migration of murine leukemia WEHI-3 cells and their tumorigenicity in a BALB/c allograft tumor model.	Application : WB Reactivity : Mouse
Tzeng BH et al. Cardiovasc Res 2012; 96 (3) : 533-42 The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice.	Application : WB Reactivity : Rat

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