抗TNF alpha抗体 | Anti-TNF alpha antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, FACS, Immunoassay
Reactivity	Human, Monkey

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APPLICATION

Application Note

For FACS, IA, and WB: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW	26 kDa. ( Note )
Specificity/Sensitivity	The antibody can be used for neutralization of human and monkey TNF-alpha in bio-assays.

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PROPERTIES

Form	Liquid
Buffer	Phosphate Buffered Saline containing 0.1% BSA and 0.02% sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Concentration	0.1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Purification	IgG fraction
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Tumor Necrosis Factor , Dif , Tnf-Alpha , Tnfa , Tnfsf2 , Tnlg1F , Tnf
Cellular Localization	Type 2 membrane protein or soluble form derived from the membrane by proteolytic cleavage.
Background	Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide stimulated macrophages, and causes tumor necrosis when injected into tumour bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS PAGE under non reducing conditions. TNF alpha is closely related to the 25 kDa protein Tumour Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
Database	・ Gene ID: 7124 ・ UniProt: P01375

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