抗beta Catenin [6F9]抗体 | Anti-beta Catenin [6F9] antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

	WB analysis of 1(1) HeLa (2) MBDK (3) MDCK (4) NRK (5) 3T3 (6) Chicken fibroblast cells using GTX26300 beta Catenin antibody[6F9] at 1:500.
	ICC/IF analysis of MDCK cells using GTX26300 beta Catenin antibody[6F9] at 1:500 (green) with DAPI (blue).

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	6F9
Isotype	IgG1
Application	WB, ICC/IF, IHC-Fr
Reactivity	Human, Mouse, Bovine, Dog, Chicken

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	1:1,000
ICC/IF	1:1,000
IHC-Fr	Assay dependent

Not tested in other applications.

Positive Control	MDBK
Specificity/Sensitivity	The antibody does not cross-react with plakoglobin (γ-catenin).

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PROPERTIES

Form	Liquid
Buffer	Ascites, 15 mM sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Antigen Species	Chicken
Immunogen	recombinant chicken β-catenin.
Purification	Unpurified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	catenin beta 1 , CHBCAT
Background	The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kD) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 protooncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.
Database	・ Gene ID: 395964 CTNNB1

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Shin S et al. Cancer Res 2007; 67 (16) : 2071870 Involvement of RNA helicases p68 and p72 in colon cancer.	Reactivity : Human

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