抗NOTCH1 [A6]抗体 | Anti-NOTCH1 [A6] antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	A6
Isotype	IgG2b
Application	IHC-P, FACS
Reactivity	Human, Mouse

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APPLICATION

Application Note

For FACS: Use at an assay dependent dilution. For IHC-P: Use at 1/50 for 30 minute at room temperature. Staining of formalin fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10 - 20 min followed by cooling at room temperature for 20 min. Optimal dilutions / concentrations should be determined by the end user.

Calculated MW	273 kDa. ( Note )
Positive Control	Pancreas
Specificity/Sensitivity	This antibody has not been tested for its cross reactivity with Notch 2.

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PROPERTIES

Form	Liquid
Buffer	Phosphate-buffered saline, pH7.4, containing 0.2% BSA and 0.1% sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration	0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Recombinant protein encoding the ligand binding region of human Notch 1
Purification	Protein A affinity purified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Notch 1 , Aos5 , Aovd1 , Tan1 , Hn1 , Notch1
Background	The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine rich EGF like repeats in the extracellular region. Four notch genes have been described in mammals, which include notch 1. notch 2, notch 3, and notch 4(Int 3), which have been implicated in the differentiation of the nervous system and other structures. The EGF like proteins Delta and Serrate have been identified as ligands of notch 1. Mature notch proteins are heterodimeric receptors derived from the cleavage of notch preproteins into an extracellular subunit (NEC) containing multiple EGF like repeats and a transmembrane subunit including intracellular region (Ntm). Alteration of notch 1 signaling or expression may contribute to tumorigenesis.
Database	・ Gene ID: 4851 ・ UniProt: P46531

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