抗Bcl-X [2H12]抗体 | Anti-Bcl-X [2H12] antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

Formalin-fixed, paraffin-embedded human Hodgkins lymphoma stained with GTX23193 using peroxidase-conjugate and AEC chromogen. Note cell membrane staining of Reed-Sternberg cells.

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	2H12
Isotype	IgG2a
Application	WB, ICC/IF, IHC-P, FACS
Reactivity	Human, Mouse, Rat, Pig

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	Assay dependent
ICC/IF	Assay dependent
IHC-P	Assay dependent
FACS	Assay dependent

Not tested in other applications.

Calculated MW	26 kDa. ( Note )
Positive Control	Hodgkin's lymphoma
Specificity/Sensitivity	GTX23193 reacts with both Bcl-XS and Bcl-XL proteins.

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PROPERTIES

Form	Liquid
Buffer	Buffer, BSA and Azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Antigen Species	Human
Immunogen	A synthetic peptide, aa 3-14 (Cys-QSNRELVVDFLS) of human Bcl-X protein. This amino acid sequence is shared by human and murine Bcl-X protein.
Purification	Unpurified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	BCL2 like 1 , BCL-XL/S , BCL2L , BCLX , Bcl-X , PPP1R52
Cellular Localization	Mitochondrion outer membrane,Mitochondrion matrix,Cytoplasm, cytosol
Background	The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]
Database	・ Gene ID: 598 BCL2L1 ・ UniProt: Q07817 BCL2L1

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