抗TRAIL抗体 | Anti-TRAIL antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC-Fr, IP
Reactivity	Human, Mouse, Rat

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APPLICATION

Application Note

For Western Blotting, use at a dilution of 1:200 Optimal dilutions should be determined by the user.

Calculated MW	33 kDa. ( Note )
Positive Control	HeLa lysate.

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PROPERTIES

Form	Liquid
Buffer	Preservative: 0.1% Sodium Azide; Constituents: 0.2% Gelatin, PBS
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration	0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Synthetic peptide (Human) (C terminal).
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Tnf Superfamily Member 10 , Apo2L , Apo-2L , Cd253 , Tl2 , Tnlg6A , Trail , Tnfsf10
Cellular Localization	Cell Membrane
Background	Several members of the growing TNF superfamily can regulate the elimination of immune cells by inducing apoptosis (1). TRAIL (TNF-related apoptosis-inducing ligand) or APO-2L is a member of the TNF superfamily that induces apoptosis by activating the death receptors DR4 and DR5 (2,3). TRAIL is attracting great interesting as an anti-cancer agent because it can induce apoptosis in a broad range of tumor cells, but only rarely in non-transformed cells, and independently of p53 status (2&4). For a time it was a it was unclear how TRAIL could induce apoptosis in tumor cells but not in non-transformed cells, while both of the cell types expressed the DR4 and DR5 death receptors. The discovery that DcR1 or TRID are mostly expressed on normal cells but not in most cancer cell lines helped to solve the puzzle, because these proteins act as decoys for the TRAIL protein (5).
Database	・ Gene ID: 8743 ・ UniProt: P50591

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