抗p53 (phospho Ser15)抗体 | Anti-p53 (phospho Ser15) antibody

• 2025/10/01

  試薬 プレゼント

  [GNT]【数量限定】早いもの勝ち！ジェンタくんキーホルダープレゼントキャンペーン[～2025/10/31] 終了間近

  期間：2025/10/01 ～2025/10/31

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  GeneTex International Corporation（GNT）

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

Western blot analysis of extract from untreated (Lane 1) and UV treated (lane 2) HeLa cells using GTX21431.

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IP, IHC
Reactivity	Human, Mouse, Rat

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	Assay dependent
IP	Assay dependent
IHC	Assay dependent

Not tested in other applications.

Calculated MW	44 kDa. ( Note )
Specificity/Sensitivity	The phospho-p53 (Ser15) antibody detects ~53 kDa phosphorylated p53 at Ser15. It does not react with non-phosphorylated p53 or p53 phosphorylated at other sites.

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PROPERTIES

Form	Liquid
Buffer	Phosphate-buffered saline, pH 7.2, containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Synthetic phospho-peptide surrounding amino acid Ser 15 of human p53.
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	tumor protein p53 , BCC7 , BMFS5 , LFS1 , P53 , TRP53
Cellular Localization	Cytoplasm,Nucleus,Endoplasmic reticulum,Mitochondrion matrix
Background	The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. p53 can apparently be phosphorylated by ATM, ATR, and DNA-PK at Ser15; the phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and functional activation of p53 in response to DNA damage.
Database	・ Gene ID: 7157 TP53 ・ UniProt: P04637 TP53

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Mladenov E et al. Sci Rep 2019; 9 (1) : 8255 Radiation-dose-dependent functional synergisms between ATM
Nana AW et al. Horm Cancer 2018; (Epub) Nano-Diamino-Tetrac (NDAT) Enhances Resveratrol-Induced Antiproliferation by Action on the RRM2 Pathway in Colorectal Cancers.	Application : WB Reactivity : Human
Cheng TM et al. Food Chem Toxicol 2017; (Epub) Resveratrol induces sumoylated COX-2-dependent anti-proliferation in human prostate cancer LNCaP cells.	Application : WB Reactivity : Human
Arumugam A et al. Cancer Biol Ther 2014; 15 (1) : 26-34 Neem leaf extract inhibits mammary carcinogenesis by altering cell proliferation, apoptosis, and angiogenesis.	Application : WB Reactivity : Rat
Li LH et al. PLoS One 2014; 9 (8) : e104203 hinokitiol induces dna damage and autophagy followed by cell cycle arrest and senescence in *-resistant lung adenocarcinoma cells.	Application : WB Reactivity : Human

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