抗GP IIb/IIIa [237]抗体 | Anti-GP IIb/IIIa [237] antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	237
Isotype	IgG1
Application	WB
Reactivity	Human

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APPLICATION

Application Note

This antibody, used at a concentration of 10-20μg/mL will allow visualization of NP 40 solubized normal human platelets

Specificity/Sensitivity	Under reducing conditions, this antibody will bind against the human platelet membrane glycoproteins IIb and/or IIIa, which have molecular weights of ~130,000 (IIb) and 115,000 (IIIa).

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PROPERTIES

Form	Liquid
Buffer	Phosphate-buffered saline, pH 7.2
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	109 human platelets suspension. The supernatant fluid from positive clones was screened by ELISA coated with washed platelets
Purification	Protein G purified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms

CD61, GP3A, HPA3, Integrin beta3 antibody, Integrin beta 3 antibody, Integrin alpha2b, Integrin alpha 2b, GPIIIa, CD41b, GP IIb/IIIa, GPIIIb, GTA, CD41, GP2B, GPIIb

Background

The integrins are a family of more than 23 heterodimeric transmembrane proteins that mediate cell-cell adhesions as well as cell-substratum adhesions and signal transduction processes. Integrins are heterodimers consisting of noncovalently associated alpha and beta subunits. CD61 non-covalently associates with CD41 (alpha Ilb integrin) and is expressed by megakaryocytes and platelets. The CD61/CD41 complex acts as a receptor for such adhesive ligands as fibronectin, fibrinogen and von Willebrand factor during platelet stimulation.

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