抗Integrin beta 1 / CD29 [4B7]抗体 | Anti-Integrin beta 1 / CD29 [4B7] antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	4B7
Isotype	IgG1
Application	ICC/IF, IHC-P, FACS, IP
Reactivity	Human

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APPLICATION

Application Note

FACS: Use at an assay dependent dilution. IF: 1/125 - 1/250. IHC-P: 1/125 - 1/250. IP: Use at 2μg/mg of lysate. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW	88 kDa. ( Note )
Positive Control	Human spleen, thymus or tonsil
Specificity/Sensitivity	Specific for integrin beta-1 subunit or CD29, which runs at 110 kDa non-reduced and at 130 kDa reduced.

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PROPERTIES

Form	Liquid
Buffer	Phosphate-buffered saline
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Human ocular melanoma cell line V + B2
Purification	Protein A purified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Integrin Subunit Beta 1 , Cd29 , Fnrb , Gpiia , Mdf2 , Msk12 , Vla-Beta , Vlab , Itgb1
Cellular Localization	Type 1 membrane protein
Background	Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6, also known as CD49a, CD49b, CD49c, CD49d, CD49e, and CD49f, respectively) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. The clustering of integrins on a cell surface leads to the formation of focal contacts. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression.
Database	・ Gene ID: 3688 ・ UniProt: P05556

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