抗ICAM1 / CD54 [15.2]抗体 | Anti-ICAM1 / CD54 [15.2] antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	15.2
Isotype	IgG1
Application	WB, FACS, IP, Blocking, IHC
Reactivity	Human, Mouse, Rabbit

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APPLICATION

Application Note

FACS: Use at an assay dependent concentration. IHC: Use at an assay dependent concentration. IP: Use at an assay dependent concentration. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW	58 kDa. ( Note )
Positive Control	Tonsil
Specificity/Sensitivity	Blocks binding of LFA-1 & infected RBCs to ICAM1.

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PROPERTIES

Form	Liquid
Buffer	Phosphate buffered saline
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Human monocytes.
Purification	Protein A purified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Intercellular Adhesion Molecule 1 , Bb2 , Cd54 , P3.58 , Icam1
Cellular Localization	Type I membrane protein
Background	ICAM1 is a 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. It shares considerable amino acid sequence homology with ICAM3 and with ICAM2. ICAM1 is expressed by activated endothelial cells. It is detected on cells of many other lineages (e.g. epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase in inflammation. Also, ICAM1 is detected in some carcinoma and melanoma cells. Soluble ICAM1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes. It is the receptor for rhinoviruses and malaria.
Database	・ Gene ID: 3383 ・ UniProt: P05362

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Chiang HY et al. J Biomed Sci 2019; 26 (1) : 61 MFG-E8 mediates arterial aging by promoting the proinflammatory phenotype of vascular smooth muscle cells.	Application : WB Reactivity : Mouse
Lin JC et al. Neoplasia 2019; 21 (5) : 459-468 Musashi-1 Enhances Glioblastoma Migration by Promoting ICAM1 Translation.	Application : FACS Reactivity : Human
Fan JR et al. Cell Death Dis 2018; 9 (5) : 502 Potential role of CBX7 in regulating pluripotency of adult human pluripotent-like olfactory stem cells in stroke model.	Application : FACS Reactivity : Human
Tran DQ et al. J Immunol 2009; 182 (5) : 2929-38 Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function.	Application : Blocking Reactivity : Mouse
Lee TC et al. PLoS One 2014; 9 (11):e111390 Comparison of Surface Markers between Human and Rabbit Mesenchymal Stem Cells.	Application : FACS Reactivity : Human, Rabbit

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