抗PPAR gamma抗体 | Anti-PPAR gamma antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

目次に戻る

価格

目次に戻る

製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC-P
Reactivity	Human, Mouse, Rat, Bovine, Dog, Hamster, Pig

目次に戻る

APPLICATION

Application Note

WB: 1/400. Predicted molecular weight: 58 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW	58 kDa. ( Note )
Positive Control	3T3-L1
Specificity/Sensitivity	will recognize both PPARgamma1 and PPARgamma2

目次に戻る

PROPERTIES

Form	Liquid
Buffer	Preservative: 0.1% Sodium Azide. Constituents: 0.2% Gelatin, PBS
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration	0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	The peptide used as the immunogen is contained within the region 410 aa to 460 aa from the human PPARgamma protein.
Purification	Protein A purified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

目次に戻る

TARGET

Synonyms	Peroxisome Proliferator Activated Receptor Gamma , Cimt1 , Glm1 , Nr1C3 , Pparg1 , Pparg2 , Ppargamma , Pparg
Cellular Localization	Nuclear
Background	Peroxisome proliferators are non genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed peroxisome proliferator activated receptors (PPARs). Nuclear hormone receptors are ligand dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPARs are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY14,643, as well as by some fatty acids. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase & cytochrome P450 (CYP450) A6 through interaction with specific response elements. The PPAR gamma 2 isoform appears to be induced very early in the differentiation of several cultured adipocyte cell lines, and has been suggested to be a dominant regulator of the murine P2 (aP2) gene which encodes an intracellular lipid binding protein which is expressed only in adipose cells. PPAR gamma 2, like several other nuclear hormone receptors, heterodimerizes with RXR alpha.
Database	・ Gene ID: 5468 ・ UniProt: P37231

目次に戻る

REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Hwang HJ et al. J Cell Physiol 2018; (Epub) zafirlukast promotes * secretion by increasing calcium influx through l-type calcium channels.	Application : IHC-P Reactivity : Rat
Jhuang HJ et al. Oncotarget 2015; 6 (10) : 7788-803 Gluconeogenesis, lipogenesis, and HBV replication are commonly regulated by PGC-1α-dependent pathway.	Application : WB Reactivity : Human
Davide P et al. Cell Mol Gastroenterol Hepatol 2015; 1 (6) : 646-663 Lipid-Induced Hepatocyte-Derived Extracellular Vesicles Regulate Hepatic Stellate Cells via MicroRNA Targeting Peroxisome Proliferator-Activated Receptor γ.	Application : WB Reactivity : Human
Ho FM et al. J Ethnopharmacol 2012; 142 (1) : 175-87 Anti-atherosclerotic action of Ger-Gen-Chyn-Lian-Tang and AMPK-dependent lipid lowering effect in hepatocytes.
Sarruf DA et al. Endocrinology 2009; 150 (2) : 707-12 Expression of peroxisome proliferator-activated receptor-gamma in key neuronal subsets regulating glucose metabolism and energy homeostasis.	Application : IHC-P Reactivity : Rat

目次に戻る