抗CD59 [MEM-43] (FITC)抗体 | Anti-CD59 [MEM-43] (FITC) antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

FACS analysis of HL-60 (positive) and SP2 (negative) cells using GTX18237 CD59 antibody [MEM-43] (FITC).

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	MEM-43
Isotype	IgG2a
Application	FACS
Reactivity	Human, Rabbit

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
FACS	20 μl reagent / 100 μl of whole blood or 10⁶ cells in a suspension

Not tested in other applications.

Calculated MW	14 kDa. ( Note )
Specificity/Sensitivity	This antibody reacts with well defined epitope (W40, R-53) on CD59 (Protectin). This antibody does not compete with MEM-43/5.

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PROPERTIES

Form	Liquid
Buffer	PBS, 15mM sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.
Concentration	Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Thymocytes and T lymphocytes
Purification	Purified by size-exclusion chromatography
Conjugation	Fluorescein isothiocyanate (FITC)
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	CD59,CD59 molecule,EJ16,EJ30,EL32,G344,HRF20,MACIF,MACIP,MEM43,MIC11,MIN1,MIN2,MIN3,MIRL,MSK21,p1820,CD59 molecule (CD59 blood group),1F5,16.3A5
Cellular Localization	Cell membrane,Secreted
Background	This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Database	・ Gene ID: 966 CD59 ・ UniProt: P13987 CD59

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Lee TC et al. PLoS One 2014; 9 (11) : e111390 Comparison of Surface Markers between Human and Rabbit Mesenchymal Stem Cells.	Application : FACS Reactivity : Human, Rabbit

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