抗alpha Smooth Muscle Actin [0.N.5]抗体 | Anti-alpha Smooth Muscle Actin [0.N.5] antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

IHC-P analysis of human leiomyoma tissue using GTX18147 alpha Smooth Muscle Actin antibody [0.N.5].

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	0.N.5
Isotype	IgG2a
Application	ICC/IF, IHC-P, IHC
Reactivity	Human, Mouse

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
ICC/IF	Assay dependent
IHC-P	1:800 for 20 minutes at RT
IHC	Assay dependent

Not tested in other applications.

Calculated MW	42 kDa. ( Note )
Specificity/Sensitivity	Recognizes human alpha-smooth muscle isoform of actin. Stains smooth muscle cells in vessel walls, gut wall and myometrium. Myoepithelial cells in breast and salivary gland are also stained. Reacts with tumors arising from smooth muscles and myoepithelial cells.

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PROPERTIES

Form	Liquid
Buffer	PBS pH 7.4, 0.2% BSA, 0.09% sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	N-terminal decapeptide of the alpha smooth muscle isoform of Actin; acetylated at the N-terminus. Epitope: Acetyl group and the first 4 amino acids on the N-terminal end of the peptide chain of alpha-smooth Actin.
Purification	Protein A purified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	AAT6,ACTA2,ACTSA,MYMY5,actin, alpha 2, smooth muscle, aorta,SMA,alpha smooth muscle Actin,alpha sma,α-SMA,a-SMA,α_SMA,actin alpha 2, smooth muscle
Cellular Localization	Cytoplasm,Cytoskeleton
Background	This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome. [provided by RefSeq, Sep 2017]
Database	・ Gene ID: 59 ACTA2 ・ UniProt: P62736 ACTA2

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Riggle BA et al. J Clin Invest 2019; (Epub) CD8+ T cells target cerebrovasculature in children with cerebral malaria.	Application : IHC-P Reactivity : Human
Otto C et al. Exp Ther Med 2012; 3 (3) : 410-414 Use of a murine endometriosis interna model for the characterization of compounds that effectively treat human endometriosis.	Application : IHC-P Reactivity : Mouse
Klarquist J et al. Am J Pathol 2009; 175 (6) : 2463-72 Melanoma-associated antigen expression in lymphangioleiomyomatosis renders tumor cells susceptible to cytotoxic T cells.	Application : IHC Reactivity : Human

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