抗CD45R [RA3-6B2] (FITC)抗体 | Anti-CD45R [RA3-6B2] (FITC) antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Rat
Clonality	Monoclonal
Clone Name	RA3-6B2
Isotype	IgG2a
Application	ICC/IF, FACS
Reactivity	Mouse

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APPLICATION

Application Note

FACS: Use 0.25μg for 10^6 cells. IF: Use at a dilution of 1/1000. Optimal dilutions/concentrations should be determined by the end user.

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PROPERTIES

Form	Liquid
Buffer	Preservative: 0.1% Sodium Azide; Constituents: PBS, 1mg/ml BSA
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Protect from light.
Concentration	0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Mouse
Immunogen	Abelson murine leukemia virus-induced pre-B tumor cells.
Purification	Protein G purified
Conjugation	Fluorescein isothiocyanate (FITC)
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Cellular Localization

Cell Membrane

Background

CD45R is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45R contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. CD45R also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Nagashima T et al. Am J Pathol 2011; 178 (1) : 222-32 Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help.

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