抗Perforin [CB5.4]抗体 | Anti-Perforin [CB5.4] antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Rat
Clonality	Monoclonal
Clone Name	CB5.4
Isotype	IgG2a
Application	WB, ICC/IF, IHC-P, IP
Reactivity	Mouse

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	1 μg/mL
ICC/IF	Assay dependent
IHC-P	Assay dependent
IP	Assay dependent

Not tested in other applications.

Calculated MW	62 kDa. ( Note )

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PROPERTIES

Form	Liquid
Buffer	PBS with 0.02% sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Concentration	Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species	Mouse
Immunogen	Perforin (monoclonal CB5.4) antibody was raised against a recombinant mouse perforin, amino acids 98-534.
Purification	Purified IgG2a
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	perforin 1 (pore forming protein) , Pfn , Pfp , Prf-1
Cellular Localization	Secreted,Cell membrane; Multi-pass membrane protein
Background	Perforin is one of the major cytolytic proteins of cytolytic granules. One of the main pathways of lymphocyte mediated cytolysis entails the secretion onto target membranes of cytolytic granules contained in cytolytic effector lymphocytes of T-cell or NK-cell type. Perforin is a cytolytic mediator and is stored in and released by cytoplasmic granules. Perforin (PRF) is involved in the killing mediated by cytotoxic lymphocytes which represents an important mechanism in the immune defense against tumors and virus infections. Human PRF is a 555 amino acid protein with a 21 amino acid signal peptide. It has a molecular weight of 70 to 75 kD. PRF is a pore forming protein with a mechanism of transmembrane channel formation similar to C9 and homology between perforin and C9 has been demonstrated at their respective functionally conserved regions. Studies show that perforin is expressed only in killer cell lines and not in helper T lymphocytes or other tumor cells tested.
Database	・ Gene ID: 18646 Prf1 ・ UniProt: P10820 Prf1

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