抗ACE2抗体 | Anti-ACE2 antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

	WB analysis of human kidney lysate using GTX15349 ACE2 antibody. Working concentration : 2 μg/ml
	IHC-P analysis of human kidney tissue using GTX15349 ACE2 antibody. Working concentration : 2 μg/ml
	IHC-P analysis of human kidney tissue using GTX15349 ACE2 antibody. Working concentration : 2 μg/ml

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, ICC/IF, IHC-P, ELISA
Reactivity	Human

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	0.5 - 2 μg/mL
ICC/IF	Assay dependent
IHC-P	2 μg/mL
ELISA	Assay dependent

Not tested in other applications.

Calculated MW	92 kDa. ( Note )
Positive Control	Human Kidney Tissue Lysate(GTX29995)
Specificity/Sensitivity	Anti-ACE2 has no cross response to ACE1.

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PROPERTIES

Form	Liquid
Buffer	PBS with 0.02% sodium azide.
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	ACE2 antibody was raised against a synthetic peptide corresponding to amino acids near the center of human ACE2.The immunogen is located within amino acids 150 - 200 of ACE2.
Purification	Purified by antigen-affinity chromatography
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	angiotensin I converting enzyme 2 , ACEH
Cellular Localization	Cytoplasm
Background	Angiotensin converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. ACE1 inhibitors such as catopril and lisinopril do not block ACE2 activity. ACE2 is restricted to the testis, heart, kidney and colon. The full length sequence for ACE2 encodes an 805 amino acid protein with predicted mass of 92.46 kDa and a pI of 5.22. No cross reactivity to ACE1.
Database	・ Gene ID: 59272 ACE2 ・ UniProt: Q9BYF1 ACE2

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