抗S100 beta抗体 | Anti-S100 beta antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

Western blot of S100b with GTX14688. Antibody Dilution 1:500. 15% disconineous gel

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, ICC/IF, IP, IHC
Reactivity	Human, Mouse

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APPLICATION

Application Note

IHC: Use at a dilution of 1/250. IP: Use at a dilution of 1/250. WB: Use at a dilution of 1/500. Detects a band of approximately 12 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW	11 kDa. ( Note )
Specificity/Sensitivity	Does not cross react with other calcium binding proteins including calbindin, calretinin or parvalbumins.

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PROPERTIES

Form	Liquid
Buffer	PH 7.4, phosphate buffer, stabilizing proteins (includes BSA) and 0.02% Sodium Azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	0.6 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Full length native protein homodimer (purified) (Human).
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	S100 Calcium Binding Protein B , Nef , S100 , S100-B , S100Beta , S100B
Background	This protein is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
Database	・ Gene ID: 6285 ・ UniProt: P04271

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Birbrair A et al. PLoS One 2011; 6 (2) : e16816 Nestin-GFP transgene reveals neural precursor cells in adult skeletal muscle.	Application : ICC/IF Reactivity : Mouse
Li YF et al. J Neurosci 2011; 31 (1) : 172-83 Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling.	Application : IHC Reactivity : Mouse
Li YF et al. Neuropsychopharmacology 2009; 34 (11) : 2404-19 Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampus.	Application : IHC Reactivity : Mouse

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