抗Rb cleaved [172C1094]抗体 | Anti-Rb cleaved [172C1094] antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

WB analysis of HL-60 cells treated with camptothecin for 24 hours using GTX13905 Rb cleaved antibody [172C1094].

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	172C1094
Isotype	IgG1
Application	WB, IHC-P, IHC-Fr
Reactivity	Human, Mouse

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	2 μg/ml
IHC-P	Assay dependent
IHC-Fr	1:10 - 1:500

Not tested in other applications.

Calculated MW	106 kDa. ( Note )
Specificity/Sensitivity	The antibody recognizes cleaved Rb (DRb-p70). The antibody does not recognize full-length Rb.

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PROPERTIES

Form	Liquid
Buffer	PBS, 0.05% BSA, 0.05% Sodium Azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb was used as immunogen.
Purification	Protein G purified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	RB transcriptional corepressor 1 , OSRC , PPP1R130 , RB , p105-Rb , pRb , pp110
Cellular Localization	Nucleus
Background	The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq]
Database	・ Gene ID: 5925 RB1 ・ UniProt: P06400 RB1

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Liu HP et al. Cell Prolif 2005; 38 (1) : 13-24 A novel form of pRb expressed during normal myelopoiesis and in tumour-associated macrophages.	Reactivity : Human

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