抗CD40抗体 | Anti-CD40 antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

"Western blot analysis of CD40: Lane 1: MWM Lane 2: ESK4 cell lysate Lane 3: Molt 4 cell lysate."

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB
Reactivity	Human, Mouse, Rat, Rabbit, Sheep, Dog, Hamster, Guinea pig, Pig, Monkey

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APPLICATION

Application Note

Recommended dilutions: WB: 1/1000. Detects a band of approximately 45 kDa (predicted molecular weight: 34 kDa). Optimal dilutions/concentrations should be determined by the end user.

Calculated MW	31 kDa. ( Note )
Positive Control	Rat Testes Tissue Extract
Specificity/Sensitivity	The antibody specificity is confirmed by specific peptide inhibition in immunoblotting studies.

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PROPERTIES

Form	Liquid
Buffer	PBS containing 50% glycerol and 0.09% sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Synthetic peptide: CQPVTQEDGKESRISVQERQ conjugated to KLH, corresponding to amino acids 258-277 of Human CD40.
Purification	Affinity purified with antigen
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Cd40 Molecule , Bp50 , Cdw40 , Tnfrsf5 , P50 , Cd40
Cellular Localization	Type I membrane protein (isoforms I, III, IV and V); secreted (isoform II).
Background	CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40 ligand (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40 predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin.
Database	・ Gene ID: 958 ・ UniProt: P25942

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