抗SOD1抗体 | Anti-SOD1 antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

Western blot analysis: rat brain tissue extract, probed with Cu/Zn SOD pAb.

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, ELISA, IHC
Reactivity	Human, Mouse, Rat, Rabbit, Sheep, Bovine, Dog, Hamster, Pig, Monkey, Xenopus laevis

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APPLICATION

Application Note

ELISA: Use at an assay dependent dilution. IHC: Use at a concentration of 1 μg/ml. WB: Use at a concentration of 1 μg/ml. Detects a band of approximately 19 and 23 kDa (predicted molecular weight: 18 kDa). Optimal dilutions/concentrations should be determined by the end user.

Calculated MW	16 kDa. ( Note )
Positive Control	HeLa cell lysate

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PROPERTIES

Form	Liquid
Buffer	Preservative: 0.1% Sodium Azide; Constituents: 50% Glycerol, 0.1M Sodium Phosphate. pH 7.0
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Rat
Immunogen	Full length protein (Rat).
Purification	Immunogen affinity purified This antibody was purified on an antigen coupled sepharose column.
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Superoxide Dismutase 1 , Cuznsod , Sod1
Cellular Localization	Cytoplasmic
Background	Superoxide dismutase (SOD) is responsible for the elimination of cytotoxic active oxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogen peroxide. There are three SOD isoenzymes in mammalian cells. They are: extracellular SOD (EC SOD), copper and zinc-containing SOD (CuZn SOD) and manganese-containing SOD (Mn SOD). The CuZn form contains Cu and Zn ions and exists as a 32 kDa dimer in the cytosol. Mn SOD is an 80 kDa tetramer that contains Mn ion and resides in the mitochondrial matrix. Mn SOD is a tumor necrosis factor (TNF)- inducible enzyme that protects cells from TNF-mediated apoptosis via superoxide anion detoxification and the subsequent regulation of apoptosis through cytochrome c release and the modulation of the redox state of the mitochondria. Mn SOD has also been shown to be a tumor suppressor in human breast cancer. Overexpression of this enzyme protects neurons from NMDA- and nitric oxide-induced neurotoxicity.
Database	・ Gene ID: 24786 ・ UniProt: P07632

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Sajja VS et al. Neurosci Lett 2014; Hippocampal vulnerability and subacute response following varied blast magnitudes.	Application : IHC Reactivity : Rat

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