TACE/ADAM17 組換え体(リコンビナント)タンパク質 | Recombinant Human TACE/ADAM17
掲載日情報：2015/01/26 現在Webページ番号：113275
R&D Systems社製の高品質なTACE/ADAM17の組換え体タンパク質(Recombinant Human TACE/ADAM17)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2024年04月29日 13時55分現在]
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TACE, Human, Recombinant, Carrier-free <ADAM17> |
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[在庫・価格 ：2024年04月29日 13時55分現在]
TACE, Human, Recombinant, Carrier-free <ADAM17>
文献数： 24
- 商品コード：930-ADB-010
- メーカー：RSD
- 包装：10μg
- 価格：¥100,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：カルタヘナ該当品
| 説明文 |
産生：Sf 21 (baculovirus)，純度：>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Human，M.W.：52 kDa，Genbank：6868，エンドトキシンレベル：<1.0 EU per 1 µg of the protein by the LAL method. 別名：ADAM 17 Genbank No： 6868 Protein Accession No： P78536.1 |
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| 法規制等 | カルタヘナ該当品 | ||
| 保存条件 | -20℃ | 法規備考 | |
| 掲載カタログ |
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| 製品記事 |
ADAM DuoSet Kit |
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| 関連記事 | |||
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Arg215-Asn671, with a C-terminal 6-His tag
- Accession
- P78536.1
- Structure
- Mature form. Recombinant Human TACE/ADAM17 is prone to proteolytic cleavage at C-terminus. The predominant form of the purified protein lacks the His tag.
- Purity
- >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 52 kDa
- SDS-PAGE
- 64 kDa, reducing conditions
- Activity
- Measured by its ability to cleave a fluorogenic peptide substrate Mca-PLAQAV-Dpa-RSSSR-NH2 (Catalog # ES003).The specific activity is >500 pmol/min/µg, as measured under the described conditions.
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Additional Information
- Molecule Information
- TACE/ADAM17
- Aliases
- ADAM17; CD156b
- Entrez Gene IDs
- 6868 (Human); 11491 (Mouse)
- Background
- ADAMs (A Disintegrin and Metalloprotease)
- Members of the ADAM or MDC (Metalloprotease, Disintegrin, Cysteine-rich) family contain pro, metalloprotease-like, disintegrin-like, cysteine-rich, transmembrane and cytoplasmic domains. They play a fundamental role in diverse processes such as asthma, development, angiogenesis and cancer through their activities in cell adhesion/fusion, membrane protein shedding, and signal transduction. Over 30 members have been identified and about half of them are active metalloproteases such as ADAM8, 9, 10, 12 and 17/TACE.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
A disintegrin and metalloenzyme (ADAM) 17 activation is regulated by ??5??1 integrin in kidney mesangial cells.
Dang Y, Gooz M, Gooz P, Haycraft CJ, Higashiyama S, Twal WO
PLoS ONE 2012 7:e33350
Species: Human
Protein Application: Enzyme Activity
Unlike for human monocytes after LPS activation, release of TNF-?? by THP-1 cells is produced by a TACE catalytically different from constitutive TACE.
Dumont S, Hentsch D, Kessler P, Moreira-Tabaka H, Muller CD, Peluso J, Reimund JM, Vonesch JL
PLoS ONE 2012 7:e34184
Species: Human
Protein Application: Enzyme Activity
Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases.
Fraemohs L, Hackeng TM, Koenen RR, Lindbom L, Ludwig A, Pruessmeyer J, Reiss K, Sarabi A, Schwarz N, Soehnlein O, Weber C, Zernecke A
Blood 2009 113:4799-809
Species: Human
Protein Application: Bioassay
Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1.
Alessi MC, Bonardo B, Boulanger CM, Canault M, Leroyer AS, Leseche G, Nalbone G, Peiretti F, Tedgui A
Am. J. Pathol. 2007 171:1713-23
Species: Human
Protein Application: Bioassay
The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events.
Bartsch JW, Bomar M, Dempsey P, Gillispie PA, Lenhart PM, Liu Q, Moss ML, Palmisano R, Sage H, Stoeck A, Wildeboer D, Zhou P
J. Biol. Chem. 2007 282:35712-21
Species: Human
Protein Application: Bioassay
Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme.
Hiraoka Y, Kita T, Nishi E, Okawa K, Yoshida K
J. Biol. Chem. 2006 281:31164-72
Species: Human
Protein Application: Bioassay
Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency.
Hinkle CL, Lee DC, Loiselle D, Parker CE, Russell WE, Stevenson M, Sunnarborg SW
J. Biol. Chem. 2004 279:24179-88
Species: Mouse
Protein Application: Enzyme Activity
Depletion of cellular cholesterol and lipid rafts increases shedding of CD30.
Borchmann P, Engert A, Hansen HP, Kallen KJ, Lange H, von Strandmann EP, von Tresckow B
J. Immunol. 2004 172:4324-31
Species: N/A
Protein Application: Western Blot Control
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