TSLP 組換え体(リコンビナント)タンパク質 | Recombinant Mouse TSLP
掲載日情報：2015/01/26 現在Webページ番号：113006
R&D Systems社製の高品質なTSLPの組換え体タンパク質(Recombinant Mouse TSLP)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年04月30日 12時35分現在]
| 詳細 | 商品名 |
|
文献数 | ||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
TSLP, Mouse, Recombinant |
|
22 | |||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||
|
TSLP, Mouse, Recombinant, Carrier-free |
|
0 | |||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||
[在庫・価格 ：2025年04月30日 12時35分現在]
TSLP, Mouse, Recombinant
文献数： 22
- 商品コード：555-TS-010
- メーカー：RSD
- 包装：10μg
- 価格：¥90,000
- 在庫：無(発注済)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：NS0，純度：>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Mouse，M.W.：15 kDa，Genbank：85480，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：thymic stromal lymphopoietin Genbank No： 85480 Protein Accession No： NP_067342 |
||
|---|---|---|---|
| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 掲載カタログ |
|
||
| 製品記事 | Helper T Cells Marker Antibodies |
||
| 関連記事 | |||
TSLP, Mouse, Recombinant, Carrier-free
文献数： 0
- 商品コード：555-TS-010/CF
- メーカー：RSD
- 包装：10μg
- 価格：¥90,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：NS0，純度：>95%, by SDS-PAGE under reducing conditions and visualized by silver stain，由来動物：Mouse，M.W.：15 kDa，Genbank：85480，エンドトキシンレベル：<0.1 EU per 1 µg of the protein by the LAL method. 別名：thymic stromal lymphopoietin Genbank No： 85480 Protein Accession No： NP_067342 |
||
|---|---|---|---|
| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 掲載カタログ |
|
||
| 製品記事 | Helper T Cells Marker Antibodies |
||
| 関連記事 | |||
追加しました。
バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
追加しました。
CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
追加しました。
Product Details
- Source
- Mouse myeloma cell line, NS0-derived, Tyr20-Glu140, with a C-terminal 10-His tag
- Accession
- NP_067342
- Purity
- >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 15 kDa
- SDS-PAGE
- 22-29 kDa, reducing conditions
- Activity
- Measured in a cell proliferation assay using BaF3 mouse pro‑B cells transfected with mouse IL-7 R alpha.The ED50 for this effect is typically 0.5 - 2.5 ng/mL.
追加しました。
Additional Information
- Molecule Information
- TSLP
- Aliases
- undefined
- Entrez Gene IDs
- 85480 (Human); 53603 (Mouse)
- Background
- Thymic Stromal Lymphopoietin (TSLP) and Receptor
- Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. The activities of mouse TSLP overlap with, but are distinct from, those of mouse IL-7. Both mouse TSLP and IL-7 can co-stimulate growth of thymocytes and mature T cells, and support B lymphopoiesis in long-term cultures of fetal liver cells and bone-marrow cells. Whereas mouse IL-7 facilitates the development of B220+/IgM- pre-B cells, mouse TSLP promotes the development B220+/IgM+ B cells. Human TSLP was reported to preferentially stimulate myeloid cells, inducing the release of T cell-attracting chemokines from monocytes and enhancing the maturation of CD11c+ dendritic cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence. Within the mature region, six of the seven cysteine residues present in the mouse TSLP involved in intramolecular disulfide bond formation are conserved in the human TSLP. Human TSLP shares approximately 43% aa sequence identity with mouse TSLP. By Northern blot analysis, human TSLP expression has been detected in many tissues with the highest expressions in heart, liver, testis and prostate. TSLP signals through a heterodimeric receptor complex that consists of IL-7 R alpha and the TSLP R, a member of the hemopoietin receptor family most closely related to Rgammac.TSLP R, also named Delta and CRLM-2 (Cytokine Receptor-like Module-2), was originally cloned as a novel type 1 cytokine receptor with similarity to the common gamma chain (gamma c). It was subsequently identified as a subunit of the cellular receptor for the IL-7-like cytokine TSLP and termed TSLP R. TSLP R shows 24%sequence identity with the mouse gc receptor. TSLP R expression is constitutive in immune and hematopoietic cells, but is up-regulated in Th2 cells.
追加しました。
Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, Is crucial for murine asthma.
Arae K, Broide D, Cua D, Ishii A, Iwakura Y, Kajiwara N, Korner H, Matsumoto K, Morita H, Nakae S, Nakanishi W, Nambu A, Oboki K, Ohno T, Ohta K, Okumura K, Saito H, Shibui A, Shimura E, Sudo K, Suto H, Suzukawa K, Suzukawa M, Yamaguchi S, Yamasoba T, Yoshimoto T
J Immunol 2012 189:3641-52
Species: Mouse
Protein Application: Bioassay
Peroxisome proliferator-activated receptor gamma-mediated suppression of dendritic cell function prevents the onset of atopic dermatitis in NC/Tnd mice.
Fujita H, Jee Y, Jung K, Karasawa K, Matsuda A, Matsuda H, Ohmori K, Oida K, Okamoto N, Shin T, Tanaka A
J. Allergy Clin. Immunol. 2011 127:420-29
Species: Mouse
Protein Application: Bioassay
IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin.
Oh MH, Oh SY, Yu J
J. Immunol. 2011 186:7232-42
Species: Mouse
Protein Application: Bioassay
Preclinical Evaluation of Local JAK1 and JAK2 Inhibition in Cutaneous Inflammation.
Burn T, Collier P, Collins R, Contel N, Fridman JS, Friedman SM, Haley P, Hertel D, Hollis G, Metcalf B, Neilan CL, Newton RC, Rodgers JD, Scherle PA, Shepard S, Shi J, Thomas B, Vaddi K, Yeleswaram S
J. Invest. Dermatol. 2011 131:1838-44
Species: Mouse
Protein Application: In Vivo
TSLP conditions the lung immune environment for the generation of pathogenic innate and antigen-specific adaptive immune responses.
Aye T, Comeau MR, Headley MB, Shih WX, Zhou B, Ziegler SF
J. Immunol. 2009 182:1641-7
Species: Mouse
Protein Application: In Vivo
Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma.
Angkasekwinai P, Barranco WT, Corry DB, Dong C, Goswami S, Greenlee KJ, Kheradmand F, Polikepahad S, Redding D, Seryshev A, Shan M, Singh B, Song LZ, Sur S, Woodruff P
Nat. Immunol. 2009 10:496-503
Species: Mouse
Protein Application: in vitro cleavage assay
MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.
Allenspach EJ, Artis D, Comeau MR, Du Y, Giacomin PR, Laufer TM, Nair MG, Pearce EJ, Perrigoue JG, Saenz SA, Siracusa MC, Taylor BC, Van Rooijen N, Zaph C
Nat. Immunol. 2009 10:697-705
Species: Mouse
Protein Application: In Vivo
A mechanism for the initiation of allergen-induced T helper type 2 responses.
Barton GM, Farr AG, Medzhitov R, Sokol CL
Nat. Immunol. 2008 9:310-8
Species: Mouse
Protein Application: Bioassay
Thymic stromal lymphopoietin and thymic stromal lymphopoietin-conditioned dendritic cells induce regulatory T-cell differentiation and protection of NOD mice against diabetes.
Amrani A, Besin G, Dupuis G, Gaudreau S, Guindi C, Menard M
Diabetes 2008 57:2107-17
Species: Mouse
Protein Application: Bioassay
IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development.
Burchill MA, Farrar MA, Mahmud SA, Vang KB, Vegoe AL, Yang J
J. Immunol. 2008 181:3285-90
Species: Mouse
Protein Application: Bioassay
追加しました。
製品情報は掲載時点のものですが、価格表内の価格については随時最新のものに更新されます。お問い合わせいただくタイミングにより製品情報・価格などは変更されている場合があります。
表示価格に、消費税等は含まれていません。一部価格が予告なく変更される場合がありますので、あらかじめご了承下さい。