IL-3 組換え体(リコンビナント)タンパク質 | Recombinant Mouse IL-3
掲載日情報：2015/01/26 現在Webページ番号：112662
R&D Systems社製の高品質なIL-3の組換え体タンパク質(Recombinant Mouse IL-3)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年04月28日 16時55分現在]
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[在庫・価格 ：2025年04月28日 16時55分現在]
IL-3, Mouse, Recombinant
文献数： 106
- 商品コード：403-ML-050
- メーカー：RSD
- 包装：50μg
- 価格：¥116,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：E. coli，純度：>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Mouse，M.W.：15 kDa，Genbank：3562，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：Hematopoietic growth factor Genbank No： 3562 Protein Accession No： NP_034686 |
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| 別包装品 | 別包装品あり | ||||||
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| 保存条件 | -20℃ | 法規備考 | |||||
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| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） |
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Recombinant Mouse IL-3, CF
文献数： 0
- 商品コード：403-ML-050/CF
- メーカー：RSD
- 包装：50μg
- 価格：¥116,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：E. coli，純度：>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Mouse，M.W.：15 kDa，Genbank：3562，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：Hematopoietic growth factor Genbank No： 3562 Protein Accession No： NP_034686 |
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|---|---|---|---|---|---|---|---|
| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 掲載カタログ |
|
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| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） |
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| 関連記事 | |||||||
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- E. coli-derived, Asp33-Cys166, with an N-terminal Met
- Accession
- NP_034686
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 15 kDa
- Activity
- Measured in a cell proliferation assay using NFS‑60 mouse myelogenous leukemia lymphoblast cells. Holmes, K.L. et al. (1985) Proc. Natl. Acad. Sci. USA 82
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Additional Information
- Molecule Information
- IL-3
- Aliases
- undefined
- Entrez Gene IDs
- 3562 (Human); 16187 (Mouse); 24495 (Rat)
- Background
- IL-3
- Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. In addition, IL-3 also affects the functional activity of mature mast cells, basophils, eosinophils and macrophages. Because of its multiple functions and targets, it was originally studied under different names, including mast cell growth factor P-cell stimulating factor, burst promoting activity, multi-colony stimulating factor, thy-1 inducing factor and WEHI-3 growth factor. In addition to activated T cells, other cell types such as human thymic epithelial cells, activated mouse mast cells, mouse keratinocytes and neurons/astrocytes can also produce IL-3. At the amino acid sequence level, mature human and mouse IL-3 share only 29% sequence identity. Consistent with this lack of homology, IL-3 activity is highly species-specific and human IL-3 does not show activity on mouse cells. IL-3 exerts its biological activities through binding to specific cell surface receptors. The high affinity receptor responsible for IL-3 signaling is composed of alpha and beta subunits. The IL-3 R alpha is a member of the cytokine receptor super family and binds IL-3 with low affinity. Two distinct beta subunits, AIC2A (betaIL-3) and AIC2B (betac) are present in mouse cells. BetaIL-3 also binds IL-3 with low affinity and forms a high affinity receptor with the alpha subunit. The betac subunit does not bind any cytokine but forms functional high affinity receptors with the alpha subunit of the IL-3, IL-5 and GM-CSF receptors. Receptors for IL-3 are present on bone marrow progenitors, macrophages, mast cells, eosinophils, megakaryocytes, basophils and various myeloid leukemic cells.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.
Abdel-Wahab O, Bhagwat N, Cremers S, Gautier E, Levine R, Lutjohann D, Randolph G, Shih A, Tall A, Westerterp M, Yvan-Charvet L
J Exp Med 2013 210:339-53
Species: Mouse
Protein Application: Bioassay
Regulation of innate CD8+ T-cell activation mediated by cytokines.
Proc Natl Acad Sci U S A 2012 109:9971-6
Cyclin D1 regulates p27(Kip1) stability in B cells.
Bustany S, Sola B, Tchakarska G
Cell. Signal. 2011 23:171-9
Species: Mouse
Protein Application: Bioassay
Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells.
Broxmeyer HE, Hangoc G, Kinzfogl J
Blood 2011 118:565-75
Species: Mouse
Protein Application: Bioassay
Differential but competitive binding of Nogo protein and class i major histocompatibility complex (MHCI) to the PIR-B ectodomain provides an inhibition of cells.
Endo S, Kitaguchi K, Kobayashi E, Kobayashi K, Kuroki K, Maenaka K, Matsushita H, Nakamura A, Sakamoto Y, Soderhall A, Strittmatter SM, Takai T
J. Biol. Chem. 2011 286:25739-47
Species: Mouse
Protein Application: Bioassay
Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
Abe Y, Arita S, Ikuta K, Itoh N, Kamada H, Katayama K, Kayamuro H, Kiyono H, Kubota-Koketsu R, Kunisawa J, Mori Y, Nagano K, Nomura T, Okamoto S, Tsunoda S, Tsutsumi Y, Yoshikawa T, Yoshioka Y
J. Virol. 2010 84:12703-12
Species: Mouse
Protein Application: In Vivo
Insertional gene activation by lentiviral and gammaretroviral vectors.
Bokhoven M, Collins MK, Gevers EF, Knight S, Robinson IC, Stephen SL, Takeuchi Y
J. Virol. 2009 83:283-94
Species: Mouse
Protein Application: Bioassay
MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.
Allenspach EJ, Artis D, Comeau MR, Du Y, Giacomin PR, Laufer TM, Nair MG, Pearce EJ, Perrigoue JG, Saenz SA, Siracusa MC, Taylor BC, Van Rooijen N, Zaph C
Nat. Immunol. 2009 10:697-705
Species: Mouse
Protein Application: Bioassay
Commonly dysregulated genes in murine APL cells.
DiPersio JF, Holt MS, Ley TJ, Link DC, Payton JE, Watson MA, Yuan W
Blood 2007 109:961-70
Species: Mouse
Protein Application: In Vivo
Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells.
Choi Y, Emerson SG, Garrett R, Hexner E, Joe GJ, Jung Y, Kim N, Taichman RS, Wang J, Zhang Y, Zhu J
Blood 2007 109:3706-12
Species: Mouse
Protein Application: Bioassay
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