Flt-3 Ligand 組換え体(リコンビナント)タンパク質 | Recombinant Human Flt-3 Ligand
掲載日情報：2015/01/26 現在Webページ番号：112383
R&D Systems社製の高品質なFlt-3 Ligandの組換え体タンパク質(Recombinant Human Flt-3 Ligand)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年06月30日 20時55分現在]
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Flt-3 Ligand, Human, Recombinant <Flk-2 Ligand> |
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Flt-3 Ligand, Human, Recombinant, Carrier-free <Flk-2 Ligand> |
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[在庫・価格 ：2025年06月30日 20時55分現在]
Flt-3 Ligand, Human, Recombinant <Flk-2 Ligand>
文献数： 48
- 商品コード：308-FK-025
- メーカー：RSD
- 包装：25μg
- 価格：¥123,000
- 在庫：2個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：Sf 21 (baculovirus)，純度：>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Human，M.W.：17.5 kDa，Genbank：2323，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：FL Genbank No： 2323 Protein Accession No： AAA17999.1 |
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| 別包装品 | 別包装品あり | ||||||
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| 保存条件 | -20℃ | 法規備考 | |||||
| 掲載カタログ |
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| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） |
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| 関連記事 | R&D Systems 製品WHO Unit Conversion Table |
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Flt-3 Ligand, Human, Recombinant, Carrier-free <Flk-2 Ligand>
文献数： 1
- 商品コード：308-FK-025/CF
- メーカー：RSD
- 包装：25μg
- 価格：¥123,000
- 在庫：1個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：Sf 21 (baculovirus)，純度：>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Human，M.W.：17.5 kDa，Genbank：2323，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：FL Genbank No： 2323 Protein Accession No： AAA17999.1 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 掲載カタログ |
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| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） |
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| 関連記事 | R&D Systems 製品WHO Unit Conversion Table |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Thr27-Pro185
- Accession
- AAA17999.1
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 17.5 kDa
- SDS-PAGE
- 17-30 kDa, reducing conditions
- Activity
- Measured in a cell proliferation assay using BaF3 mouse pro‑B cells transfected with mouse Flt-3.The ED50 for this effect is typically 0.2-1 ng/mL.
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Additional Information
- Molecule Information
- Flt-3 Ligand
- Aliases
- FLT3LG
- Entrez Gene IDs
- 2323 (Human); 14256 (Mouse); 493796 (Feline)
- Background
- Flt-3 Ligand
- Flt-3 Ligand, also known as FL, is an alpha-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. Mature human Flt-3 Ligand consists of a 158 amino acid (aa) extracellular domain (ECD) with a cytokine-like domain and a juxtamembrane tether region, a 21 aa transmembrane segment, and a 30 aa cytoplasmic tail. Within the ECD, human Flt-3 Ligand shares 71% and 65% aa sequence identity with mouse and rat Flt-3 Ligand, respectively. Human and mouse Flt-3 Ligand show cross-species activity. Flt-3 Ligand is expressed as a noncovalently-linked dimer by T cells and bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of N- and O-linked carbohydrates. Alternate splicing and proteolytic cleavage of the transmembrane form can generate a soluble 30 kDa fragment that includes the cytokine domain. Alternate splicing of human Flt-3 Ligand also generates membrane-associated isoforms that contain either a truncated cytoplasmic tail or an 85 aa substitution following the cytokine domain. Both transmembrane and soluble Flt-3 Ligand signal through the tyrosine kinase receptor Flt-3/Flk-2. Flt-3 Ligand induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. It synergizes with IL-3, GM-CSF, and SCF to promote the mobilization and myeloid differentiation of hematopoietic stem cells. It cooperates with IL-2, -6, -7, and -15 to induce NK cell development and with IL-3, -7, and -11 to induce terminal B cell maturation. Animal studies also show Flt-3 Ligand to reduce the severity of experimentally induced allergic inflammation.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Burton L, Chan E, Fridlyand J, Koeppen H, Li J, Lin E, Merchant M, Moffat J, Neve R, Peng J, Penuel E, Ribas A, Settleman J, Sosman J, Sutherlin DP, Wang Y, Wilson TR, Yan Y
Nature 2012 487:505-9
Species: Human
Protein Application: Bioassay
A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors.
Heike T, Niwa A, Umeda K
PLoS ONE 2011 6:e22261
Species: Human
Protein Application: Bioassay
Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases.
Chang JC, Kan YW, Lin C, Sun X, Ye L, Yu J
Proc. Natl. Acad. Sci. U.S.A. 2009 106:9826-30
Species:
Protein Application: Bioassay
Refreezing of cord blood hematopoietic stem cells for allogenic transplantation: in vitro and in vivo validation of a clinical phase I/II protocol in European and Italian Good Manufacturing Practice conditions.
Aglietta M, Berger M, Fagioli F, Ferrero I, Gammaitoni L, Gunetti M, Piacibello W, Rustichelli D, Timeus F
Exp. Hematol. 2008 36:235-43
Species: Human
Protein Application: Bioassay
Isolation and characterization of CD146+ multipotent mesenchymal stromal cells.
Baiocchi M, Biffoni M, Castelli G, Fatica A, Ferracin M, Negrini M, Peschle C, Sorrentino A, Tomaselli G, Valtieri M
Exp. Hematol. 2008 36:1035-46
Species: Human
Protein Application: Bioassay
Thrombopoietin enhances generation of CD34+ cells from human embryonic stem cells.
Carrier E, Esmaeli-Azad B, Mishra R, Nedelcu E, Srivastava AS
Stem Cells 2007 25:1456-61
Species: Human
Protein Application: Bioassay
Effects of busulfan dose escalation on engraftment of infant rhesus monkey hematopoietic stem cells after gene marking by a lentiviral vector.
Burns TS, Choi C, Dorey FJ, Fisher J, Fletcher MD, Jimenez DF, Kahl CA, Kohn DB, Leapley AC, Lee CI, Pepper K, Petersen D, Tarantal AF, Ultsch MN
Exp. Hematol. 2006 34:369-81
Species: Primate - Macaca mulatta (Rhesus monkey)
Protein Application: Bioassay
Long-lasting in vitro hematopoiesis derived from primate embryonic stem cells.
Aoki N, Danjo I, Fujioka T, Hiroyama T, Miharada K, Nagasawa T, Nakamura Y, Sudo K
Exp. Hematol. 2006 34:760-9
Species: Primate ? Macaca fascicularis (Cynomolgus/Crab-eating Monkey)
Protein Application: Bioassay
Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells.
Dong Y, Hashiguchi T, Hiroyama T, Imoto H, Izawa K, Kurita R, Maeda T, Nakazaki Y, Sasaki E, Soda Y, Suehiro Y, Takasugi K, Tani K, Tanioka Y, Yokoo T
Stem Cells 2006 24:2014-22
Species: Primate - Callitrix jacchus (common marmoset)
Protein Application: Bioassay
The reduction of in vitro radiation-induced Fas-related apoptosis in CD34+ progenitor cells by SCF, FLT-3 ligand, TPO, and IL-3 in combination resulted in CD34+ cell proliferation and differentiation.
Drouet M, Grenier N, Herodin F, Mathieu J, Multon E, Sotto JJ
Stem Cells 1999 17:273-85
Species: Primate - Baboon
Protein Application: Bioassay
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