IL-6 R alpha 組換え体(リコンビナント)タンパク質 | Recombinant Human IL-6 R alpha
掲載日情報：2015/01/26 現在Webページ番号：112032
R&D Systems社製の高品質なIL-6 R alphaの組換え体タンパク質(Recombinant Human IL-6 R alpha)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2024年05月18日 08時15分現在]
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IL-6 Receptor α, Human, Recombinant |
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IL-6 Receptor α, Human, Recombinant, Carrier-free |
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[在庫・価格 ：2024年05月18日 08時15分現在]
IL-6 Receptor α, Human, Recombinant
文献数： 34
- 商品コード：227-SR-025
- メーカー：RSD
- 包装：25μg
- 価格：¥100,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
産生：Sf 21 (baculovirus)，純度：>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Human，M.W.：38 kDa，Genbank：3570，エンドトキシンレベル：<1.0 EU per 1 µg of the protein by the LAL method. 別名：IL-6 R，IL-6Ra，IL6R，IL-6R alpha，IL-6R α Genbank No： 3570 Protein Accession No： P08887.1 |
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| 保存条件 | -20℃ | 法規備考 | |
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| 製品記事 |
Helper T Cells Marker Antibodies |
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IL-6 Receptor α, Human, Recombinant, Carrier-free
文献数： 0
- 商品コード：227-SR-025/CF
- メーカー：RSD
- 包装：25μg
- 価格：¥100,000
- 在庫：3個以上
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
産生：Sf 21 (baculovirus)，純度：>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Human，M.W.：38 kDa，Genbank：3570，エンドトキシンレベル：<1.0 EU per 1 µg of the protein by the LAL method. 別名：IL-6 R，IL-6Ra，IL6R，IL-6R alpha，IL-6R α Genbank No： 3570 Protein Accession No： P08887.1 |
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| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 掲載カタログ |
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||
| 製品記事 |
Helper T Cells Marker Antibodies |
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| 関連記事 | |||
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Leu20-Asp358
- Accession
- P08887.1
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 38 kDa
- SDS-PAGE
- 45-50 kDa, reducing conditions
- Activity
- Measured by its ability to enhance the IL-6 activity on M1 mouse myeloid leukemia cells. Saito, T. et al. (1991) J. Immunol. 147
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Additional Information
- Molecule Information
- IL-6 R alpha
- Aliases
- CD126; IL6R
- Entrez Gene IDs
- 3570 (Human); 16194 (Mouse)
- Background
- IL-6 Receptor alpha
- The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6 R) and a signal-transducing component of 130 kDa (gp 130) that does not bind IL-6 by itself, but is required for high-affinity binding of IL-6 by the complex. A soluble form of the IL-6 R alpha has been found in the urine of healthy adult humans. This soluble receptor apparently arises from proteolytic cleavage of membrane-bound IL-6 R alpha. No naturally-occurring mRNA encoding a truncated form of the IL-6 R alpha has been reported. Soluble forms of human and murine IL-6 R alphas have been constructed, however, by insertion of termination codons into the regions of the IL-6 R alpha cDNAs encoding the external portions of the receptors and prior to the transmembrane domains. These soluble receptors have been expressed in COS-7 and CHO cells and have been shown to bind to IL-6 in solution and to augment the activity of IL-6 as a result of the binding of the IL-6/IL-6 R alpha complex to membrane-bound gp130.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Soluble interleukin-6 receptor induces motor stereotypies and co-localizes with gp130 in regions linked to cortico-striato-thalamo-cortical circuits.
Banks W, Kuzhikandathil E, Patel A, Siegel A, Zalcman S, Zhu Y
PLoS ONE 2012 7:e41623
Species: Mouse
Protein Application: In Vivo
Oligo-guanosine nucleotide induces neuropilin-1 internalization in endothelial cells and inhibits angiogenesis.
Hou X, Li X, Narazaki M, Segarra M, Tanaka T, Tosato G
Blood 2010 116:3099-107
Species: Human
Protein Application: Blocking
Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells.
Ara T, DeClerck YA, Groshen SG, Keshelava N, Metelitsa LS, Russell HV, Seeger RC, Shimada H, Song L
Cancer Res. 2009 69:329-37
Species: Human
Protein Application: Bioassay
Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes.
Loeser RF, Long D, Yammani RR
Arthritis Rheum. 2009 60:792-800
Species: Human
Protein Application: Bioassay
A novel ultra-sensitive enzyme immunoassay for soluble human insulin receptor ectodomain and its measurement in urine from healthy subjects and patients with diabetes mellitus.
Nishioka M, Obata T, Umehara A
Clin. Biochem. 2009 42:1468-75
Species: N/A
Protein Application: ELISA Standard
Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production.
Ahmed S, Campbell PL, Koch AE, Kwan K, Marotte H, Pakozdi A, Rabquer BJ, Ruth JH
Proc. Natl. Acad. Sci. U.S.A. 2008 105:14692-7
Species: Human
Protein Application: Bioassay
Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle.
Alkhouri H, Ammit AJ, Black JL, Burgess JK, Ge Q, Hughes JM, Moir LM, Oliver BG, Roth M
Am. J. Physiol. Lung Cell Mol. Physiol. 2007 292:L199-206
Species: Human
Protein Application: Bioassay
trans fatty acids and systemic inflammation in heart failure.
King IB, Lawler RL, Levy WC, McDonald GB, Mozaffarian D, Rimm EB
Am. J. Clin. Nutr. 2004 80:1521-5
Species: N/A
Protein Application: ELISA Standard
CD14 is an acute-phase protein.
Bas S, Gabay C, Gauthier BR, Spenato U, Stingelin S
J. Immunol. 2004 172:4470-9
Species: Human
Protein Application: Bioassay
Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells.
Fuller GM, Hurst SM, Jones SA, McLoughlin RM, Monslow J, Morgan L, Owens S, Topley N
J. Immunol. 2002 169:5244-51
Species: N/A
Protein Application: ELISA Standard
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