GM-CSF 組換え体(リコンビナント)タンパク質 | Recombinant Human GM-CSF
掲載日情報:2015/01/26 現在Webページ番号:111971
R&D Systems社製の高品質なGM-CSFの組換え体タンパク質(Recombinant Human GM-CSF)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 :2025年04月26日 00時00分現在]
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[在庫・価格 :2025年04月26日 00時00分現在]
GM-CSF, Human, Recombinant
文献数: 254
- 商品コード:215-GM-010
- メーカー:RSD
- 包装:10μg
- 価格:¥57,000
- 在庫:2個
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | 産生:E. coli,純度:>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.,由来動物:Human,M.W.:14 kDa,Genbank:1437,エンドトキシンレベル:<1.0 EU per 1 µg of the protein by the LAL method. 別名:colony stimulating factor 2 (granulocyte-macrophage) Genbank No: 1437 Protein Accession No: CAA26822 |
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別包装品 | 別包装品あり | ||||||
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保存条件 | -20℃ | 法規備考 | |||||
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製品記事 | 抗幹細胞マーカー抗体/抗造血幹細胞マーカー抗体(R&D Systems社) StemXVivo Dendritic Cell Base Media |
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関連記事 |
GM-CSF, Human, Recombinant, Carrier-free
文献数: 0
- 商品コード:215-GM-010/CF
- メーカー:RSD
- 包装:10μg
- 価格:¥57,000
- 在庫:1個
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | 産生:E. coli,純度:>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.,由来動物:Human,M.W.:14 kDa,Genbank:1437,エンドトキシンレベル:<1.0 EU per 1 µg of the protein by the LAL method. 別名:colony stimulating factor 2 (granulocyte-macrophage) Genbank No: 1437 Protein Accession No: CAA26822 |
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別包装品 | 別包装品あり | ||||||
法規制等 | |||||||
保存条件 | -20℃ | 法規備考 | |||||
掲載カタログ |
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製品記事 | 抗幹細胞マーカー抗体/抗造血幹細胞マーカー抗体(R&D Systems社) StemXVivo Dendritic Cell Base Media |
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関連記事 |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
追加しました。
CF(Carrier-Free)とは?
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- E. coli-derived, Ala18-Glu144
- Accession
- CAA26822
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 14 kDa
- Activity
- Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140
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Additional Information
- Molecule Information
- GM-CSF
- Aliases
- CSF2
- Entrez Gene IDs
- 1437 (Human); 12981 (Mouse); 116630 (Rat); 397208 (Porcine); 403923 (Canine); 493805 (Feline)
- Background
- GM-CSF
- GM-CSF was initially characterized as a factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is also a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. GM-CSF is produced by a number of different cell types (including T cells, B cells, macrophages, mast cells, endothelial cells, fibroblasts, and adipocytes) in response to cytokine or inflammatory stimuli. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages, and eosinophils. GM-CSF promotes a Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity. It shows clinical effectiveness in ameliorating chemotherapy-induced neutropenia, and GM-CSF transfected tumor cells are utilized as cancer vaccines. The 22 kDa glycosylated GM-CSF, similar to IL-3 and IL-5, is a cytokine with a core of four bundled alpha helices. Mature human GM-CSF shares 63% - 70% amino acid sequence identity with canine, feline, porcine, and rat GM-CSF and 54% with mouse GM-CSF. GM-CSF exerts its biological effects through a heterodimeric receptor complex composed of GM-CSF R alpha/CD116 and the signal transducing common beta chain (CD131) which is also a component of the high-affinity receptors for IL-3 and IL-5. In addition, GM-CSF binds a naturally occurring soluble form of GM-CSF R alpha. Human GM-CSF is active on canine and feline cells but not on murine cells.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Erythropoietin mimetic compound AGEM400(HES) binds to the same receptor as erythropoietin but displays a different spectrum of activities.
Breuer B, Emgenbroich M, Frank HG, Greindl A, Haberl U, Kessler C, Potgens AJ, Rybka A
Cytokine 2012 57:226-37
Species: Human
Protein Application: Bioassay
Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite.
Emara M, Mahdavi J, Royer PJ
J. Biol. Chem. 2012 287:5756-63
Species: Human
Protein Application: Bioassay
Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency.
Kawamura T, Nakamura Y, Ogawa Y
J. Clin. Invest. 2012 122:722-32
Species: Human
Protein Application: Bioassay
Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation.
Bellati F, Belleudi F, Clausen H, Frati L, Irimura T, Napoletano C, Nuti M, Pierelli L, Rahimi H, Rughetti A, Wandall HH, Zizzari IG
Eur. J. Immunol. 2012 42:936-45
Species: Human
Protein Application: Bioassay
Leishmania amazonensis impairs DC function by inhibiting CD40 expression via A2B adenosine receptor activation.
Afonso LC, Figueiredo AB, Marques-da-Silva EA, Meyer-Fernandes JR, Serafim TD
Eur. J. Immunol. 2012 42:1203-15
Species: Mouse
Protein Application: Bioassay
The C-type Lectin Receptor CLECSF8 (CLEC4D) Is Expressed by Myeloid Cells and Triggers Cellular Activation through Syk Kinase.
Brown GD, Campanero-Rhodes MA, Dennehy KM, Feizi T, Graham LM, Guler R, Gupta V, Hornsell WG, Kim SK, Kimberg M, Palma AS, Reid DM, Schafer G, Sobieszczuk P, Willment JA
J. Biol. Chem. 2012 287:25964-74
CD34-derived dendritic cells transfected ex vivo with HIV-Gag mRNA induce polyfunctional T-cell responses in nonhuman primates.
Eur. J. Immunol. 2012 42:2019-30
Species: Primate - Macaca fascicularis (Crab-eating or Cynomolgus macaque)
Protein Application: Bioassay
Nitric oxide-producing myeloid-derived suppressor cells inhibit vascular E-selectin expression in human squamous cell carcinomas.
J. Invest. Dermatol. 2012 132:2642-51
Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth.
Apetoh L, Boireau W, Bruchard M, Chalmin F, Chevriaux A, Connat J, Derangere V, Ghiringhelli F, Kanellopoulos J, Martin F, Mignot G, Rebe C, Ryffel B, Simon B, Vegran F
Nat Med 2012 19:57-64
Species: Human
Protein Application: Cell Culture Substrate
HDAC inhibition by LBH589 affects the phenotype and function of human myeloid dendritic cells.
Anderson KC, Chauhan D, Exley MA, Hideshima T, Munshi NC, Nanjappa P, Song W, Tai YT, Tian Z
Leukemia 2011 25:161-8
Species: h
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