TSLP 組換え体(リコンビナント)タンパク質 | Recombinant Human TSLP
掲載日情報：2015/01/26 現在Webページ番号：111658
R&D Systems社製の高品質なTSLPの組換え体タンパク質(Recombinant Human TSLP)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年08月13日 00時01分現在]
| 詳細 | 商品名 |
|
文献数 | ||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
TSLP, Human, Recombinant |
|
30 | |||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||
|
TSLP, Human, Recombinant, Carrier-free |
|
0 | |||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||
[在庫・価格 ：2025年08月13日 00時01分現在]
TSLP, Human, Recombinant
文献数： 30
- 商品コード：1398-TS-010
- メーカー：RSD
- 包装：10μg
- 価格：¥71,000
- 在庫：1個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：E. coli，純度：>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Human，M.W.：15 kDa，Genbank：85480，エンドトキシンレベル：<0.10 EU per 1 μg of the protein by the LAL method. 別名：thymic stromal lymphopoietin Genbank No： 85480 Protein Accession No： Q969D9.1 |
||
|---|---|---|---|
| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 掲載カタログ |
|
||
| 製品記事 | Helper T Cells Marker Antibodies |
||
| 関連記事 | |||
TSLP, Human, Recombinant, Carrier-free
文献数： 0
- 商品コード：1398-TS-010/CF
- メーカー：RSD
- 包装：10μg
- 価格：¥71,000
- 在庫：1個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：E. coli，純度：>95%, by SDS-PAGE under reducing conditions and visualized by silver stain，由来動物：Human，M.W.：15 kDa，Genbank：85480，エンドトキシンレベル：<0.10 EU per 1 μg of the protein by the LAL method. 別名：thymic stromal lymphopoietin Genbank No： 85480 Protein Accession No： Q969D9.1 |
||
|---|---|---|---|
| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 掲載カタログ |
|
||
| 製品記事 | Helper T Cells Marker Antibodies |
||
| 関連記事 | |||
追加しました。
バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
追加しました。
CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
追加しました。
Product Details
- Source
- E. coli-derived, Tyr29-Gln159, with an N-terminal Met
- Accession
- Q969D9.1
- Purity
- >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 15 kDa
- Activity
- Measured in a cell proliferation assay using BaF3 mouse pro‑B cells co-transfected with human IL-7 R alphaand human TSLP R. Reche, P.A. et al. (2001) J. Immunol. 167
追加しました。
Additional Information
- Molecule Information
- TSLP
- Aliases
- undefined
- Entrez Gene IDs
- 85480 (Human); 53603 (Mouse)
- Background
- Thymic Stromal Lymphopoietin (TSLP) and Receptor
- Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. The activities of mouse TSLP overlap with, but are distinct from, those of mouse IL-7. Both mouse TSLP and IL-7 can co-stimulate growth of thymocytes and mature T cells, and support B lymphopoiesis in long-term cultures of fetal liver cells and bone-marrow cells. Whereas mouse IL-7 facilitates the development of B220+/IgM- pre-B cells, mouse TSLP promotes the development B220+/IgM+ B cells. Human TSLP was reported to preferentially stimulate myeloid cells, inducing the release of T cell-attracting chemokines from monocytes and enhancing the maturation of CD11c+ dendritic cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence. Within the mature region, six of the seven cysteine residues present in the mouse TSLP involved in intramolecular disulfide bond formation are conserved in the human TSLP. Human TSLP shares approximately 43% aa sequence identity with mouse TSLP. By Northern blot analysis, human TSLP expression has been detected in many tissues with the highest expressions in heart, liver, testis and prostate. TSLP signals through a heterodimeric receptor complex that consists of IL-7 R alpha and the TSLP R, a member of the hemopoietin receptor family most closely related to Rgammac.TSLP R, also named Delta and CRLM-2 (Cytokine Receptor-like Module-2), was originally cloned as a novel type 1 cytokine receptor with similarity to the common gamma chain (gamma c). It was subsequently identified as a subunit of the cellular receptor for the IL-7-like cytokine TSLP and termed TSLP R. TSLP R shows 24%sequence identity with the mouse gc receptor. TSLP R expression is constitutive in immune and hematopoietic cells, but is up-regulated in Th2 cells.
追加しました。
Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Macrophages participate in IL-17-mediated inflammation.
Baldeviano GC, Barin JG, Caturegli P, Chen P, Cihakova D, Ong S, Quader F, Rose NR, Talor MV, Wu L, Zheng D
Eur. J. Immunol. 2012 42:726-36
Species: Mouse
Protein Application: Bioassay
IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces Proinflammatory Cytokine Production and Th17 Cell Generation.
Audran M, Barre B, Blanchard S, Bouvard B, Corvaisier M, Delneste Y, Garo E, Hoppe E, Jeannin P, Jeanvoine H, Preisser L, Saint-Andre J
PLoS Biol 2012 10:e1001395
IL-25 in atopic dermatitis: a possible link between inflammation and skin barrier dysfunction?
Hvid M, Kemp K, Vestergaard C
J. Invest. Dermatol. 2011 131:150-7
Species: Human
Protein Application: Bioassay
Thymic stromal lymphopoietin-induced human asthmatic airway epithelial cell proliferation through an IL-13-dependent pathway.
Chakir J, Gounni AS, Jacques E, Koussih L, Semlali A
J. Allergy Clin. Immunol. 2010 125:844-50
Species: Human
Protein Application: Bioassay
TSLP and downstream molecules in experimental mouse allergic conjunctivitis.
Cunningham MA, De Paiva CS, Hwang CS, Li DQ, Ma P, Pflugfelder SC, Zheng X
Invest. Ophthalmol. Vis. Sci. 2010 51:3076-82
Species: Human
Protein Application: Bioassay
FcepsilonRI-mediated thymic stromal lymphopoietin production by interleukin-4-primed human mast cells.
Fueki M, Fukuda T, Okayama Y, Okumura S, Ra C, Sagara H, Saito H, Sasaki T, Sugiyama K, Takeda K, Watanabe N, Yuki K
Eur. Respir. J. 2009 34:425-35
Species: Human
Protein Application: Bioassay
Mycobacterium bovis Bacillus Calmette-Guerin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells.
Amakawa R, Amuro H, Fukuhara S, Ito T, Liu YJ, Son Y, Sugimoto H, Tajima K, Tanijiri T, Torii Y, Yokoi T
Int. Immunol. 2008 20:1321-9
Species: Human
Protein Application: Bioassay
Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid.
Dahinden CA, Didichenko S, Langen H, McCaffery P, Spiegl N
Blood 2008 112:3762-71
Species: Human
Protein Application: Bioassay
In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation.
Austin CD, Bullens SL, Diehl L, Fuentes ME, Graus YM, Hyde DM, Hymowitz SG, Labrijn AF, Lee WP, Martin F, Meng YG, Miller LA, Schelegle ES, Seeber S, Seshasayee D, Shu J, Suto E, Tan M, Wu LC, Zhang J, Zhou M
J. Clin. Invest. 2007 117:3868-3878
Species: Human
Protein Application: Bioassay
追加しました。
製品情報は掲載時点のものですが、価格表内の価格については随時最新のものに更新されます。お問い合わせいただくタイミングにより製品情報・価格などは変更されている場合があります。
表示価格に、消費税等は含まれていません。一部価格が予告なく変更される場合がありますので、あらかじめご了承下さい。