SLPI 組換え体(リコンビナント)タンパク質 | Recombinant Human SLPI
掲載日情報：2015/01/26 現在Webページ番号：111591
R&D Systems社製の高品質なSLPIの組換え体タンパク質(Recombinant Human SLPI)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年06月26日 19時15分現在]
| 詳細 | 商品名 |
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文献数 | ||
|---|---|---|---|---|---|
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SLPI, Human, Recombinant, Carrier-free <Secretory Leukocyte Protease Inhibitor> |
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23 | |||
[在庫・価格 ：2025年06月26日 19時15分現在]
SLPI, Human, Recombinant, Carrier-free <Secretory Leukocyte Protease Inhibitor>
文献数： 23
- 商品コード：1274-PI-100
- メーカー：RSD
- 包装：100μg
- 価格：¥68,000
- 在庫：1個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- E. coli-derived, Ser26-Ala132
- Accession
- P03973
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 12 kDa
- SDS-PAGE
- 13 kDa, reducing conditions
- Activity
- Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 (Catalog # ES002).The IC50 value is <4.0 nM, under the described conditions.
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Additional Information
- Molecule Information
- SLPI
- Aliases
- undefined
- Entrez Gene IDs
- 6590 (Human); 20568 (Mouse)
- Background
- SLPI
- Secretory leukocyte protease inhibitor (SLPI) is found in various secretory fluids including parotid secretions, bronchial, nasal, cervical mucous, and seminal fluid. SLPI is a potent inhibitor of many proteolytic enzymes including the neutrophil proteases, elastase, cathepsin G, chymotrypsin, and trypsin.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Inhibition of SLPI ameliorates disease activity in experimental autoimmune encephalomyelitis.
Conlon H, Jun E, Muller AM, Sadiq SA
BMC Neurosci 2012 13:30
Species: Human
Protein Application: Bioassay
Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).
Choi N, Lee SC, Suh HS, Tarassishin L
PLoS ONE 2012 7:e35115
Dysregulation of TIM-3-Galectin-9 Pathway in the Cystic Fibrosis Airways.
Arikawa T, Hirashima M, McElvaney NG, McNally P, Niki T, O'Neill SJ, Reeves EP, Vega-Carrascal I
J. Immunol. 2011 0:
Species: Human
Protein Application: Bioassay
The secretory leukocyte protease inhibitor (SLPI) and the secondary granule protein lactoferrin are synthesized in myelocytes, colocalize in subcellular fractions of neutrophils, and are coreleased by activated neutrophils.
Borregaard N, Cowland JB, Jacobsen LC, Sorensen OE, Theilgaard-Monch K
J. Leukoc. Biol. 2008 83:1155-64
Species: N/A
Protein Application: Western Blot Control
Use of an immunoaffinity-mass spectrometry-based approach for the quantification of protein biomarkers from serum samples of lung cancer patients.
Birse CE, Brand E, FitzHugh W, Han M, He T, Kaminker P, Kim J, Mesri M, Moore PA, Nguyen A, Nicol GR, Ruben SM
Mol. Cell Proteomics 2008 7:1974-82
Species: N/A
Protein Application: Standard
Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI.
Buldys M, Cerutti A, Chadburn A, Chiu A, Ding A, He B, Knowles DM, Santini PA, Shan M, Xu W, XuWe WNat. Immunol. 2007 8:294-303Species: HumanProtein Application: Bioassay
Nat. Immunol. 2007 8:294-303
Species: Human
Protein Application: Bioassay
Streptococcal DRS (distantly related to SIC) and SIC inhibit antimicrobial peptides, components of mucosal innate immunity: a comparison of their activities.
Binks MJ, Fernie-King BA, Lachmann PJ, Seilly DJ, Sriprakash KS
Microbes Infect. 2007 9:300-7
Species: Bacteria
Protein Application: Bioassay
The alarm anti-protease, secretory leukocyte protease inhibitor, is a proliferation and survival factor for ovarian cancer cells.
Alejandro EU, Devoogdt NM, Kamrava MM, Kohn EC, Rasool N, Simpkins FA, Tchabo NE
Carcinogenesis 2007 29:466-72
Species: N/A
Protein Application: Western Blot Control
Mannan-binding lectin-associated serine protease 3 cleaves synthetic peptides and insulin-like growth factor-binding protein 5.
Cortesio CL, Jiang W
Arch. Biochem. Biophys. 2006 449:164-70
Species: N/A
Protein Application: Enzyme Activity
Arginine-specific gingipains from Porphyromonas gingivalis deprive protective functions of secretory leucocyte protease inhibitor in periodontal tissue.
Imamura T, Inomata M, Into T, Izumi Y, Kanno Y, Machigashira M, Matsushita K, Matsuyama T, Nakashima M, Noguchi T
Clin. Exp. Immunol. 2006 145:545-54
Species: Human
Protein Application: Bioassay
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