抗ATRX抗体 (Anti-ATRX Antibody) | ヒト組織免疫染色用抗体

掲載日情報:2019/10/28 現在Webページ番号:9655

ATRXに対する抗体(Anti-ATRX Antibody)です。
高品質なTriple A Polyclonalsブランド抗体となります。

本製品は研究用です。研究用以外には使用できません。

特長

  • Atlas Antibodies社のポリクローナル抗体は「Atlas Antibodies Advanced Polyclonals」(Triple A Polyclonals)と称され、Atlas Antibodies社企業秘密のソフトウェアにより対象抗原タンパク質に対する最も適した、慎重にデザインされた抗体です。
  • アフィニティーリガンドとしてリコンビナント抗原を用いた、Atlas Antibodies社独自の抗原精製過程により、特異性・信頼性・多様性が保持されています。
  • 対応するリコンビナント抗原の取り扱いもあり(PrEST抗原)、ウエスタンブロット用のポジティブコントロール、および免疫組織染色での抗体ブロッキングに有用です。
  • すべての抗体はHuman Protein Atlas (HPA) プロジェクトにて、様々な正常組織、腫瘍組織で検証されています。
  • それぞれの抗体に対して700点以上の免疫組織染色、免疫蛍光染色、ウエスタンブロッティング像が公開されています。
Human Protein Atlas プロジェクトの詳細や、Atlas Antibodies社抗体の検証手順についてはこちらをご覧下さい。


Triple A Polyclonalsとは?

目次に戻る

価格

[在庫・価格 :2024年04月25日 00時00分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
詳細 商品名
  • 商品コード
  • メーカー
  • 包装
  • 価格
  • 在庫
  • 法規制等
納期 文献数
Anti-ATRX, Rabbit-Poly
2週間程度 ※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。 8
説明文
バリデーション情報:GENETIC, ORTHOGONAL, STANDARD
別名:JMS,RAD54,XH2,XNP
Genbank No: 546
Protein Accession No: P46100
別包装品 別包装品あり
法規制等
保存条件 -20℃ 法規備考
抗原種 Human 免疫動物 Rabbit クラス IgG 標識 Unlabeled
交差性 Human 適用 IC,IHC,Western Blot
クロナリティ Polyclonal フォーマット 性状 Antigen Affinity Purified 吸収処理
掲載カタログ

製品記事 Atlas Antibodies社文献使用抗体
Atlas Antibodies社における抗体検証の取り組み
関連記事

[在庫・価格 :2024年04月25日 00時00分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。

Anti-ATRX, Rabbit-Poly

文献数: 8

説明文 バリデーション情報:GENETIC, ORTHOGONAL, STANDARD
別名:JMS,RAD54,XH2,XNP
Genbank No: 546
Protein Accession No: P46100
別包装品 別包装品あり
法規制等
保存条件 -20℃ 法規備考
抗原種 Human 免疫動物 Rabbit
交差性 Human 適用 IC,IHC,Western Blot
標識 Unlabeled 性状 Antigen Affinity Purified
吸収処理 クラス IgG
クロナリティ Polyclonal フォーマット
掲載カタログ

製品記事 Atlas Antibodies社文献使用抗体
Atlas Antibodies社における抗体検証の取り組み
関連記事



目次に戻る

製品情報

免疫組織染色(IHC)
Staining of human liver shows no positivity in hepatocytes as expected.
Staining of human liver shows no positivity in hepatocytes as expected.

推奨プロトコル(Recommended conditions)
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

Dilution: 1:500 - 1:1000
Retrieval method: HIER pH6

ウエスタンブロッティング(WB)
Western blot analysis in human cell line A-549.
Western blot analysis in human cell line A-549.

推奨プロトコル(Recommended conditions)

Genetic validation in WB by siRNA knockdown.
Working concentration: 0.4 µg/ml

関連データベース(Database Links)
抗原情報(Antigen Sequence)
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: : AAWAEYEAEKKGLTMRFNIPTGTNLPPVSFNSQTPYIPFNLGALSAMSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWKENMNLSEAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLISCVQRILMNRR
抗体の精製方法(Purification Method)
Affinity purified using the PrEST antigen as affinity ligand
ホモロジー情報(Interspecies Information)
性状(Form)
40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
保存方法(Storage)
Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Notes
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
References
Title
Comparison among conventional and advanced MRI, 18F-FDG PET/CT, phenotype and genotype in glioblastoma
Source
Oncotarget
Valentini MC, Mellai M, Annovazzi L, Melcarne A, Denysenko T, Cassoni P, Casalone C, Maurella C, Grifoni S, Fania P, Cistaro A, Schiffer D.

Title
Primary Astrocytic Tumours and Paired Recurrences have Similar Biological Features in IDH1, TP53 and TERTp Mutation and MGMT, ATRX Loss
Source
Sci Rep
Li X, Wei J, Liu Y, Li P, Fan L, Wang Y, Li M, Zhao D, Yu Z, Ye J, Guo Y, Yan Q, Guo S, Wang Z.

Title
Reclassification of Mixed Oligoastrocytic Tumors Using a Genetically Integrated Diagnostic Approach
Source
J Pathol Transl Med
Kim SI, Lee Y, Won JK, Park CK, Choi SH, Park SH.

Title
The frequency and prognostic effect of TERT promoter mutation in diffuse gliomas
Source
Acta Neuropathol Commun
Lee Y, Koh J, Kim SI, Won JK, Park CK, Choi SH, Park SH.

Title
Expression and prognostic value of JAM-A in gliomas
Source
J Neurooncol
Rosager AM, Sørensen MD, Dahlrot RH, Boldt HB, Hansen S, Lathia JD, Kristensen BW.

Title
IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas
Source
Clin Sarcoma Res
Cleven AH, Suijker J, Agrogiannis G, Briaire-de Bruijn IH, Frizzell N, Hoekstra AS, Wijers-Koster PM, Cleton-Jansen AM, Bovée JV.

Title
PARP1 expression and its correlation with survival is tumour molecular subtype dependent in glioblastoma
Source
Oncotarget
Murnyák B, Kouhsari MC, Hershkovitch R, Kálmán B, Marko-Varga G, Klekner Á, Hortobágyi T.

Title
DAXX/ATRX and MEN1 genes are strong prognostic markers in pancreatic neuroendocrine tumors
Source
Oncotarget
Park JK, Paik WH, Lee K, Ryu JK, Lee SH, Kim YT.

Title
Somatostatin receptor 2A in gliomas: Association with oligodendrogliomas and favourable outcome
Source
Oncotarget
Kiviniemi A, Gardberg M, Kivinen K, Posti JP, Vuorinen V, Sipilä J, Rahi M, Sankinen M, Minn H.

Title
Anti-proliferative and anti-secretory effects of everolimus on human pancreatic neuroendocrine tumors primary cultures: is there any benefit from combination with somatostatin analogs?
Source
Oncotarget
Mohamed A, Romano D, Saveanu A, Roche C, Albertelli M, Barbieri F, Brue T, Niccoli P, Delpero JR, Garcia S, Ferone D, Florio T, Moutardier V, Poizat F, Barlier A, Gerard C.

Title
Alternative lengthening of telomeres in primary pancreatic neuroendocrine neoplasms is associated with aggressive clinical behavior and poor survival
Source
Clin Cancer Res
Kim JY, Brosnan-Cashman JA, An S, Kim SJ, Song KB, Kim MS, Kim MJ, Hwang DW, Meeker AK, Yu E, Kim SC, Hruban RH, Heaphy CM, Hong SM.

Title
Cancer Cells with Alternative Lengthening of Telomeres Do Not Display a General Hypersensitivity to ATR Inhibition
Source
Front Oncol
Deeg KI, Chung I, Bauer C, Rippe K.

Title
Not all 1p/19q non-codeleted oligodendroglial tumors are astrocytic
Source
Oncotarget
Li YX, Shi Z, Aibaidula A, Chen H, Tang Q, Li KK, Chung NY, Chan DT, Poon WS, Mao Y, Wu J, Zhou L, Chan AK, Ng HK.

Title
TERT promoter mutations in pancreatic endocrine tumours are rare and mainly found in tumours from patients with hereditary syndromes
Source
Sci Rep
Vinagre J, Nabais J, Pinheiro J, Batista R, Oliveira RC, Gonçalves AP, Pestana A, Reis M, Mesquita B, Pinto V, Lyra J, Cipriano MA, Ferreira MG, Lopes JM, Sobrinho-Simões M, Soares P.

Title
IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation
Source
Sci Rep
Oktay Y, Ülgen E, Can Ö, Akyerli CB, Yüksel Ş, Erdemgil Y, Durası İM, Henegariu OI, Nanni EP, Selevsek N, Grossmann J, Erson-Omay EZ, Bai H, Gupta M, Lee W, Turcan Ş, Özpınar A, Huse JT, Sav MA, Flanagan A, Günel M, Sezerman OU, Yakıcıer MC, Pamir MN, Özduman K.

Title
ATRX binds to atypical chromatin domains at the 3′ exons of zinc finger genes to preserve H3K9me3 enrichment
Source
Epigenetics
Valle-García D, Qadeer ZA, McHugh DS, Ghiraldini FG, Chowdhury AH, Hasson D, Dyer MA, Recillas-Targa F, Bernstein E.

Title
Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12
Source
PLoS Genet
Mäkinen N, Aavikko M, Heikkinen T, Taipale M, Taipale J, Koivisto-Korander R, Bützow R, Vahteristo P.

Title
TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast
Source
British Journal of Cancer
Masayuki Yoshida, Reiko Ogawa, Hiroshi Yoshida, Akiko Maeshima, Yae Kanai, Takayuki Kinoshita, Nobuyoshi Hiraoka, Shigeki Sekine.

Title
Adult Diffuse Astrocytoma in the Medulla Oblongata: Molecular Biological Analyses Including H3F3A Mutation of Histone H3.3
Source
NMC Case Rep J
Uekawa K, Nakamura H, Shinojima N, Takezaki T, Yano S, Kuratsu JI.

Title
Molecular–genetic and clinical characteristics of gliomas with astrocytic appearance and total 1p19q loss in a single institutional consecutive cohort
Source
Oncotarget
Hayashi S, Sasaki H, Kimura T, Abe T, Nakamura T, Kitamura Y, Miwa T, Kameyama K, Hirose Y, Yoshida K.

Title
ATRX represses alternative lengthening of telomeres
Source
Oncotarget
Napier CE, Huschtscha LI, Harvey A, Bower K, Noble JR, Hendrickson EA, Reddel RR.

Title
CDKN2A Loss Is Associated with Shortened Overall Survival in Lower Grade (World Health Organization II-III) Astrocytomas
Source
J Neuropathol Exp Neurol
Reis GF, Pekmezci M, Hansen HM, Rice T, Marshall RE, Molinaro AM, Phillips JJ, Vogel H, Wiencke JK, Wrensch MR, Walsh KM, Perry A.

Title
Loss of ATRX and DAXX expression identifies poor prognosis for smooth muscle tumours of uncertain malignant potential and early stage uterine leiomyosarcoma
Source
J Pathol Clin Res
Slatter TL, Hsia H, Samaranayaka A, Sykes P, Clow W(, Devenish CJ, Sutton T, Royds JA, PC P, Cheung AN, Hung NA.

Title
Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas
Source
Nature Communications
Lauren Fishbein, Sanika Khare, Bradley Wubbenhorst, Daniel DeSloover, Kurt D’Andrea, Shana Merrill, Nam Woo Cho, Roger A. Greenberg, Tobias Else, Kathleen Montone, Virginia LiVolsi, Douglas Fraker, Robert Daber, Debbie L. Cohen, Katherine L. Nathanson.

Title
Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells
Source
Acta Neuropathol
Barszczyk M, Buczkowicz P, Castelo-Branco P, Mack SC, Ramaswamy V, Mangerel J, Agnihotri S, Remke M, Golbourn B, Pajovic S, Elizabeth C, Yu M, Luu B, Morrison A, Adamski J, Nethery-Brokx K, Li XN, Van Meter T, Dirks PB, Rutka JT, Taylor MD, Tabori U, Hawkins C.

Title
Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas
Source
Oncotarget
Cryan JB, Haidar S, Ramkissoon LA, Bi WL, Knoff DS, Schultz N, Abedalthagafi M, Brown L, Wen PY, Reardon DA, Dunn IF, Folkerth RD, Santagata S, Lindeman NI, Ligon AH, Beroukhim R, Hornick JL, Alexander BM, Ligon KL, Ramkissoon SH.

Title
Benefit From Procarbazine, Lomustine, and Vincristine in Oligodendroglial Tumors Is Associated With Mutation of IDH
Source
J Clin Oncol
Cairncross JG, Wang M, Jenkins RB, Shaw EG, Giannini C, Brachman DG, Buckner JC, Fink KL, Souhami L, Laperriere NJ, Huse JT, Mehta MP, Curran WJ Jr.

Title
The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas.
Source
Mod Pathol
Abedalthagafi M, Phillips JJ, Kim GE, Mueller S, Haas-Kogen DA, Marshall RE, Croul SE, Santi MR, Cheng J, Zhou S, Sullivan LM, Martinez-Lage M, Judkins AR, Perry A.

Title
Molecular and morphologic correlates of the alternative lengthening of telomeres phenotype in high-grade astrocytomas.
Source
Brain Pathol
Nguyen DN, Heaphy CM, de Wilde RF, Orr BA, Odia Y, Eberhart CG, Meeker AK, Rodriguez FJ.

Title
Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors
Source
Mod Pathol
de Wilde RF, Heaphy CM, Maitra A, Meeker AK, Edil BH, Wolfgang CL, Ellison TA, Schulick RD, Molenaar IQ, Valk GD, Vriens MR, Rinkes IH, Offerhaus GJ, Hruban RH, Matsukuma KE.

Title
Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas
Source
Oncotarget
Jiao Y, Killela PJ, Reitman ZJ, Rasheed BA, Heaphy CM, de Wilde RF, Rodriguez FJ, Rosemberg S, Oba-Shinjo SM, Marie SK, Bettegowda C, Agrawal N, Lipp E, Pirozzi CJ, Lopez GY, He Y, Friedman HS, Friedman AH, Riggins GJ, Holdhoff M, Burger P, McLendon RE, Bigner DD, Vogelstein B, Meeker AK, Kinzler KW, Papadopoulos N, Diaz LA Jr, Yan H.

Title
Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway
Source
PLoS Genet
Lovejoy CA, Li W, Reisenweber S, Thongthip S, Bruno J, de Lange T, De S, Petrini JH, Sung PA, Jasin M, Rosenbluh J, Zwang Y, Weir BA, Hatton C, Ivanova E, Macconaill L, Hanna M, Hahn WC, Lue NF, Reddel RR, Jiao Y, Kinzler K, Vogelstein B, Papadopoulos N, Meeker AK, for the ALT Starr Cancer Consortium.

Title
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.
Source
Nature
Schwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, Jacob K, Sturm D, Fontebasso AM, Quang DA, Tönjes M, Hovestadt V, Albrecht S, Kool M, Nantel A, Konermann C, Lindroth A, Jäger N, Rausch T, Ryzhova M, Korbel JO, Hielscher T, Hauser P, Garami M, Klekner A, Bognar L, Ebinger M, Schuhmann MU, Scheurlen W, Pekrun A, Frühwald MC, Roggendorf W, Kramm C, Dürken M, Atkinson J, Lepage P, Montpetit A, Zakrzewska M, Zakrzewski K, Liberski PP, Dong Z, Siegel P, Kulozik AE, Zapatka M, Guha A, Malkin D, Felsberg J, Reifenberger G, von Deimling A, Ichimura K, Collins VP, Witt H, Milde T, Witt O, Zhang C, Castelo-Branco P, Lichter P, Faury D, Tabori U, Plass C, Majewski J, Pfister SM, Jabado N.

Title
Altered telomeres in tumors with ATRX and DAXX mutations.
Source
Science
Heaphy CM, de Wilde RF, Jiao Y, Klein AP, Edil BH, Shi C, Bettegowda C, Rodriguez FJ, Eberhart CG, Hebbar S, Offerhaus GJ, McLendon R, Rasheed BA, He Y, Yan H, Bigner DD, Oba-Shinjo SM, Marie SK, Riggins GJ, Kinzler KW, Vogelstein B, Hruban RH, Maitra A, Papadopoulos N, Meeker AK.

Title
Clinical Neuropathology practice news 2-2014: ATRX, a new candidate biomarker in gliomas
Source
Clin Neuropathol
Haberler C, Wöhrer A.

目次に戻る

抗原情報(Antigen Sequence)

Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: : AAWAEYEAEKKGLTMRFNIPTGTNLPPVSFNSQTPYIPFNLGALSAMSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWKENMNLSEAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLISCVQRILMNRR

[在庫・価格 :2024年04月25日 00時00分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
詳細 商品名
  • 商品コード
  • メーカー
  • 包装
  • 価格
  • 在庫
  • 法規制等
納期 文献数
PrEST Antigen ATRX, Human, Recombinant
ご照会下さい ※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。 0
説明文
産生:E. coli,純度:>80% by SDS-PAGE and Coomassie blue staining,濃度:≥0.5 mg/ml
別名:JMS,RAD54,XH2,XNP
Genbank No: 546
Protein Accession No: P46100
法規制等
保存条件 -20℃ 法規備考
掲載カタログ

製品記事
関連記事

[在庫・価格 :2024年04月25日 00時00分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。

PrEST Antigen ATRX, Human, Recombinant

文献数: 0

説明文 産生:E. coli,純度:>80% by SDS-PAGE and Coomassie blue staining,濃度:≥0.5 mg/ml
別名:JMS,RAD54,XH2,XNP
Genbank No: 546
Protein Accession No: P46100
法規制等
保存条件 -20℃ 法規備考
掲載カタログ

製品記事
関連記事



目次に戻る

関連製品情報


高性能な免疫組織染色用の抗原賦活化装置: 「Decloaking Chamber NxGen」 ⇒ 詳細はこちら

目次に戻る

お問い合わせ先

(テクニカルサポート 試薬担当)

reagent@funakoshi.co.jp

製品情報は掲載時点のものですが、価格表内の価格については随時最新のものに更新されます。お問い合わせいただくタイミングにより製品情報・価格などは変更されている場合があります。
表示価格に、消費税等は含まれていません。一部価格が予告なく変更される場合がありますので、あらかじめご了承下さい。