第70回日本細胞生物学会・第51回日本発生生物学会合同学会
CELLnTEC社ランチョンセミナーのお知らせ

Co-Ordinated Generation of Multiple Ocular Cell Lineages and Fabrication of Functional Corneal Epithelial Cell Sheets from Human iPS cells
Ryuhei Hayashi, PhD; Endowed Chair, Professor, Department of Stem Cells and Applied Medicine, Osaka University Graduate School of Medicine

CELLnTEC, Precision Cell Culture specialist for Research, 3D and Clinical Applications
Thomas Schnibbe, PhD; CELLnTEC Advanced Cell Systems AG, Bern, Switzerland

Key Topics:
Precision Cell Culture – Chemically Defined Media – Research to Clinical Applications

Identity and traceability of components and materials are paramount when moving from research stage into clinical phases of development. Applying the right material selection and sourcing strategies early in the research and development process can help avoid costly late-stage failures. CELLnTEC bridges both worlds with a range of animal component free and chemically defined media that can be easily upgraded for clinical applications. At the same time, they can be combined in a modular manner when moving from expansion to differentiation into a wide range of cell and tissue types. This secures maximal control of the experimental environment, minimizes variation and secures media and component continuity through all phases of the development process.

Modelling disease in 2D progenitor cell cultures: From bench to bedside of Pemphigus vulgaris patients
Prof. Eliane J. Müller, PhD; Department of BioMedical Research, Molecular Dermatology and Stem Cell Research, University of Bern, Bern, Switzerland

Key Topics:
Cadherins – Mechanical Sensing and Signalling – Stem Cell Niche Adhesion and Homeostasis – Self-Organizing Principles – Clinical Applications and Regenerative Medicine

Pemphigus vulgaris is a life-threatening autoimmune disease targeting desmosomal cadherins at the adhesive interface between stem and progenitor cells of stratified epithelia and the hair follicle bulge, one of the best-studied stem cell niches in the mammalian body. This presentation highlights how accurate disease modelling in 2D cultures led to an entirely novel, consensus-backed concept of Pemphigus vulgaris pathophysiology. Two major benefits concerning clinical applications and regenerative medicine emanate from these advances; i) novel therapies for pemphigus vulgaris patients and ii) the understanding of an unfathomed role of a desmosomal cadherins in niche homeostasis and a self-organizing repair program in the injured stem cell niche.