ヒト ニューデシン（Neudesin）定量キット Human Neudesin ELISA Kit

試料中のヒト ニューデシン（Neudesin）を、サンドイッチ法により定量するELISAキットです。ニューデシンは神経機能やエネルギー代謝、腫瘍形成などに関与しています。

※本製品は研究用です。研究用以外には使用できません。

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Human neudesin (neuron-derived neurotrophic factor) is a unique secreted protein with a conserved cytochrome 5-like heme/steroid-binding domain belonging to MAPR (membrane-associated progesterone receptor) family with multiple roles.

Neudesin is expressed in the mouse embryonic cerebral cortex and the neural precursor cells where significantly promotes neural cell differentiation and also transiently promotes neural cell proliferation during the early stages of development.

Neudesin is abundantly expressed in white adipose tissue of adult mice and also in hypothalamic nuclei that regulate food intake. The appetite-suppressing effect of neudesin was abrogated in obese mice fed a high-fat diet, demonstrating a diet-dependent modulation of neudesin function. Neudesin knockout mice were resistant to high-fat diet (HFD)-induced obesity due to elevated systemic sympathetic activity, heat production, and adipocytic lipolysis.

Neudesin is over-expressed in multiple human cancers including carcinoma of the breast, colon, lung, uterine cervix, skin and malignant lymphoma. The tumorigenesis mechanism involving neudesin might be mediated by the activation via the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways.