上皮間葉転移マーカー抗体 Antibodies for Epithelial-Mesenchymal Transition (EMT)
掲載日情報：2020/06/12 現在Webページ番号：65036
Novus Biologicals社のEMT(上皮間葉転移)マーカー抗体をご紹介します。品質が高く、使用文献が多い抗体です。
Novus Biological社のTumor hypoxia & EMTポスターはこちらからダウンロードできます。
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EMTとは
Epithelial-Mesenchymal Transition (EMT)は、非運動性上皮細胞が運動性の間葉細胞に分化転換する現象です。発生・傷の治癒・幹細胞性に関わる重要なプロセスであり、線維形成やがん転移の病態生理学研究に必須です。EMTにより、細胞の形状と遺伝子発現を調製するシグナル分子が変化することで、上皮細胞は結合極性を失い、細胞骨格を再形成します。これにより、個々の細胞は運動性を増し、浸潤性を持つようになります。分子レベルでは、SNAI1 (Zinc finger protein SNAI1), ZEB (zinc-finger E-box-binding)、bHLH factors (basic helix-loop-helix transcription factors)などの転写因子に仲介されます。
Novus Biologicals社のEMT & Stemness FAQsはこちらをご覧下さい。
Novus Biologicals社のEMT関連製品フライヤーはこちらからダウンロードできます。
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Epithelial Phenotype Markers抗体
 抗E-Cadherin抗体：Immunocytochemistry: E-Cadherin Antibody (7H12) [#NBP2-19051]– ICC staining of E-Cadherin in human colon cancer sphere. Image from verified customer review. |
 Immunohistochemistry-Paraffin: MUC-1 Antibody (SM3) [#NB120-22711] - IHC analysis of formalin fixed paraffin embedded tissue section of human breast cancer xenograft using MUC-1 antibody clone SM3 at 1:10 dilution. The xenograft section depicted a very specific and intense signal in the periphery of the cancer cells. The necrotic cells also developed a strong immune-positivity while the tumor stroma as well as the nuclei of cells were negative for immunostaining. | |
 Immunohistochemistry-Paraffin: pan Cytokeratin Antibody (AE1 + AE3) [#NBP2-29429] - Formalin-paraffin colon carcinoma stained with pan Cytokeratin Ab cocktail (AE-1 / AE3). |
| 品名 | 免疫動物／ポリ・モノクローナル | 種交差性 | 適用 |
|---|---|---|---|
| Claudin-1 | Rb/Poly | Hu, Mu, Rt | ELISA, ICC/IF, IHC-P, West |
| COL4A1 | Rb/Poly | Hu, Rt, Bv, Ma | ELISA, IHC-P, IP, West |
| pan Cytokeratin | Mu/Mono | Hu, Mu, Rt, Bv, Ca, Ch, Pm, Rb | Flow, ICC/IF, IHC-Fr, IHC-P, West |
| Cytokeratin 1 | Mu/Mono | Hu, Rt, | ICC/IF, IHC-Fr, IHC-P, West |
| Cytokeratin 18 | Mu/Mono | Hu | ELISA, Flow, ICC/IF, IHC-Fr, IHC-P, IP, SW, West |
| Desmocollin-1 | Rb/Poly | Hu | IHC-P, SW, West |
| Desmoglein 3 | Mu/Mono | Hu | IHC-PICC/IF, IHC-P, IP, West |
| Desmoplakin | Gt/Poly | Hu | IHC-P, PEP-ELISA, West |
| E-Cadherin | Mu/Mono | Hu, Mu, Rt, Pm | ELISA, Flow, ICC/IF, IHC-P, West |
| Laminin | Rb/Poly | Hu, Mu, Rt, Rb, Sh | Func, ICC/IF, IHC-Fr, IHC-P, West |
| MUC-1 | Mu/Mono | Hu, Mu | ELISA, ICC/IF, IHC-Fr, IHC-P |
| Nidogen-1 | Rb/Poly | Hu | IHC-P, West |
| Occludin | Rb/Poly | Hu, Mu, Rt | ELISA, ICC/IF, IHC-P, West |
| Syndecan-1 | Mu/Mono | Hu | Flow, Func, ICC/IF, IHC-Fr, IHC-P, West |
| TJP1/Z01 | Rb/Poly | Hu | ICC/IF, IHC-P |
※Species Key: Am (Amphibian) Av (Avian), Bv (Bovine), Ca (Canine), Ch (Chicken), Eq (Equine), Fe (Feline), Fi (Fish), Gt (Goat), Ha (H amster), Hu (Human),Ma (Mammals), Mu (Mouse), Pm (Non-human Primates), Rb (Rabbit), Rt (Rat), Sh (She ep), Xp (Xenopus)
※Applications Key: ChIP (Chromatin Immunoprecipitation), GS (Gel Super Shift Assay), ELISA (ELISA Capture and/or Detection), Flow (Flow Cytometry),Func (Functional), ICC/IF (Immunocytochemistry/Immunofluorescence), IHC-Fr (Immunohistochemistry-Frozen), IHC-P (Immunohistochemistry-Paraffin),IP (Immunoprecipitation), MiAr (Microarray), PEP-ELISA (Peptide ELISA), PLA (Proximity Ligation Assay), SW (Simple Western), West (Western blot)
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Mesenchymal Phenotype Markers抗体
 Immunocytochemistry/Immunofluorescence: Actin α 2 Smooth Muscle Antibody (1A4) [#NB600-536] - Frozen section of human small intestine immunostained with α -SM1 (1:1000). |
 Immunocytochemistry/Immunofluorescence: N-Cadherin Antibody (13A9) [#NBP1-48309] - HeLa cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were incubated with anti N-Cadherin (13A9) [#NBP1-48309] at a 1:100 dilution overnight at 4C and detected with an anti-mouse Dylight 488 (Green) at a 1:500 dilution. Actin was detected with Phalloidin 568 (Red) at a 1:200 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective. | |
 Immunocytochemistry/Immunofluorescence: Vimentin Antibody [#NB300-223] - View of mixed neuron/glial cultures stained with #NB300-223(green) and rabbit antibody to GFAP antibody #NB300-141(red). Vimentinis expressed alone in fibroblastic and endothelial cells, which are theflattened cells in the middle of the image which appear green. Astrocytesmay express primarily GFAP, or GFAP and vimentin, and so appear red(GFAP only) or golden yellow (GFAP and Vimentin). In cells whichexpress both GFAP and vimentin, the two protein assemble to produceheteropolymer filaments. | ||
| 品名 | 免疫動物／ポリ・モノクローナル | 種交差性 | 適用 |
|---|---|---|---|
| alpha SMA | Rb/Poly | Hu, Mu, Rt | ICC/IF, IHC-Fr, IHC-P, West |
| alpha SMA | Mu/Mono | Hu | ICC/IF, IHC-Fr, IHC-P, West |
| Fibronectin | Rb/Poly | Hu, Mu | ICC/IF, IHC-P, SW, West |
| N Cadherin | Mu/Mono | Hu, Mu, Rt | ICC/IF, IHC-P, IP, SW, West |
| N-Cadherin | Rb/Poly | Hu, Mu, Rt, Am, Av, Bv, Ca, Ch, Fi, Rb, Xp | ICC/IF, IHC-Fr, IHC-P, West |
| OB-Cadherin | Rb/Poly | Hu, Mu, Rt | West |
| S100A4 | Mu/Mono | Hu | ICC/IF, IHC-P, West |
| Slug | Rb/Poly | Hu, Ca, Eq | IHC-P, West |
| Snail | Rb/Poly | Hu, Mu, Ca, Eq | ICC/IF, West |
| Snail | Rb/Poly | Hu | IHC-P, SW |
| Snail(pS246) | Rb/Poly | Hu, Mu, Rt | IHC-P, West |
| Vimentin | Ck/Poly | Hu, Mu, Rt | ICC/IF, IHC-Fr, IHC-P, West |
| Vimentin | Mu/Mono | Hu, Mu, Rt, Ma | ICC/IF, IHC, SW, West |
※Species Key: Am (Amphibian) Av (Avian), Bv (Bovine), Ca (Canine), Ch (Chicken), Eq (Equine), Fe (Feline), Fi (Fish), Gt (Goat), Ha (H amster), Hu (Human),Ma (Mammals), Mu (Mouse), Pm (Non-human Primates), Rb (Rabbit), Rt (Rat), Sh (She ep), Xp (Xenopus)
※Applications Key: ChIP (Chromatin Immunoprecipitation), GS (Gel Super Shift Assay), ELISA (ELISA Capture and/or Detection), Flow (Flow Cytometry),Func (Functional), ICC/IF (Immunocytochemistry/Immunofluorescence), IHC-Fr (Immunohistochemistry-Frozen), IHC-P (Immunohistochemistry-Paraffin),IP (Immunoprecipitation), MiAr (Microarray), PEP-ELISA (Peptide ELISA), PLA (Proximity Ligation Assay), SW (Simple Western), West (Western blot)
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