アポトーシスや神経変性疾患研究に有用 小胞体ストレス応答（Unfolded Protein Response、UPR）研究用抗体

Unfolded Protein Response(UPR), the stress response that prevents accumulation of unfolded proteins in the lumen of endoplasmic reticulum, may result from conditions such as high protein demand, viral infection, mutant protein expression, hypoxia, energy deprivation, or exposure to excessive oxidative stress. Sustained over-activation of UPR has been associated with several human diseases including cancer, hyperglycemia, autoimmune conditions, hepatic disorders and neuro-degeneration. Accordingly, a complete mechanistic understanding of UPR is very critical for evaluation of its biological effects in normal or disease conditions, and for developing preventive/therapeutic measures for UPR associated diseases.