ヒト可溶性トランスフェリンレセプター測定ELISAキット Human Soluble Transferrin Receptor ELISA Kit

Transferrin Receptor (TfR) is the major mediator of iron uptake by cells (1, 2). TfR is a transmembrane, disulfide-linked dimer of two identical subunits (3 - 7) that binds and internalizes diferric transferrin, thereby delivering iron to the cell cytosol. When a cell needs iron, TfR expression is increased to facilitate iron uptake (8 - 10). Since the major use of iron is for hemoglobin synthesis, about 80% of total TfR is on erythroid progenitor cells.
sTfR is intended for use with other parameters of iron status as an aid in diagnosis of iron deficiency. Interpretation should be made with the understanding that sTfR is also elevated by hyperplastic erythropoiesis and ineffective erythropoiesis.