抗CD14 (RPA-M1)抗体 | Anti- CD14 (RPA-M1) antibody

• Image
• Background
• 価格
• 標識済み抗体価格

Image

	Immunocytochemistry/Immunofluorescence: CD14 Antibody (RPA-M1) [Azide Free] [NBP2-27215] - Analysis of CD14 in human PBMCs using anti-CD14 DyLight 405 conjugated antibody. Image from verified customer review.
	Flow Cytometry: CD14 Antibody (RPA-M1) [Azide Free] [NBP2-27215] - Cell surface analysis of CD14 using CD14 antibody. Surface staining of CD14 on 10^6 human monocytes using 0.1 ug of CD14 antibody. Shaded histogram represents cells without antibody; green represents isotype control ; red represents CD14 antibody. Flow kit and anti-mouse IgG-FITC secondary antibody was used for this test.

目次に戻る

Background

CD14 a well known cell-activating receptor for lipopolysaccharide-binding protein and peptidoglycan is an important regulator of lipopolysaccharide (LPS)-dependent signal transduction and is a part of the multi-protein complex containing at least CD14, MD-2 and TLR4. Encoded by a single-copy gene, CD14 contains 11 LRR (leucine-rich) repeats and exists in two forms a glycosylphosphatidylinositol-anchored membrane protein (mCD14) and a monocyte or liver-derived soluble serum protein (sCD14) that lacks the anchor. The soluble form of CD14 functions in LPS sensitivity to cells lacking the membrane form and its increased expression is reported to be associated with inflammatory infectious diseases and high mortality in gram-negative shock. CD14 an important component of the innate immune response preferentially expressed on mature cells of the monocytic lineage mediates the bacterial lipopolysaccharide (LPS) signaling, thus leading to NF-kappa-B activation, cytokine secretion and inflammatory response. Moreover it is also known to be involved in the clearance of apoptotic cells, up-regulation of cell surface molecules (adhesion molecules) and also in regulating IgE levels.

目次に戻る

価格

目次に戻る

標識済み抗体価格

目次に戻る