抗TLR10 (3C10C5)抗体 | Anti- TLR10 (3C10C5) antibody

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	Flow (Cell Surface): TLR10 Antibody (3C10C5) - Azide Free [NBP2-27214] - Analysis using the Alexa Fluor (R) 647 conjugate of NBP2-27214. Detection of TLR10 on human PBMC using 10 ul (1 ug) of TLR10 antibody and 1 ug of CD19 antibody.
	Flow Cytometry: TLR10 Antibody (3C10C5) - Azide Free [NBP2-27214] - Analysis using the PE conjugate of NBP2-27214. Staining of Human PBMC were probed using 10 ul (1 ug) of TLR10 antibody and 1 ug of CD19 antibody this antibody. This antibody was used for this test.

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Background

Toll-like receptors (TLRs) are one of the mechanisms by which the innate immune system senses the invasion of pathogenic microorganisms (reviewed in 1). TLRs are primary transmembrane proteins of immune cells; they have an extracellular region which contains leucine-rich repeat motifs, and a cytoplasmic tail, which has a Toll/interleukin-1 (IL-1) receptor (TIR) domain. TLRs are pattern recognition receptors (PRRs ) that bind to pathogen-associated molecular patterns (PAMPs). Different TLRs recognize different surface and intracellular components of microorganisms or PAMPS. The interaction between a TLR and a microbial component or PAMP triggers the activation of the innate immune system, as well as the development of acquired immunity. Interaction of PAMPs with different TLRs induces distinct patters of gene expression through signal transduction pathways. TLR signaling occurs through the TIR domains which utilize adaptors such as MyD88, TIRAP, TRIF, and TRAM. NF-kapppa-B and JNk pathways are activated leading to the transcription of genes encoding pro-inflammatory cytokines. TLR-10, originally identified from a spleen cDNA library, is on chromosome 4p14 and has been found to be expressed in lung and in B-lymphocytes (2). TLR10 is thought to be a potential asthma candidate gene because early life innate immune responses to ubiquitous inhaled allergens and PAMPs may influence asthma susceptibility.

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価格

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標識済み抗体価格

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