Anti-Siglec-H (23M14A10) [PE] | 抗Siglec-H (23M14A10) [PE]抗体 | Siglec-H (23M14A10) [PE] antibody

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Flow Cytometry: SiglecH Antibody (23M14A10) [PE] [NBP2-27060] - Staining of freshly isolated Balb C mouse splenocytes with B220 (clone RA3-6B2) Alexa Fluor 488 antibody and with Rat IgG2a PE (isotype control, left) or anti-mouse Siglec H PE antibody (Clone: 23M14A10, right).

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Background

Siglec-H, or sialic acid binding immunoglobulin-like lectin H, is a CD33 related protein expressed specifically by plasmacytoid dendritic cells or pDCs (1, 2). Antigen-mediated delivery by Siglec-H in pDCs inhibits Th cell proliferation and further antibody responsesThis leads to lessened expansion and Th1/Th17 polarization (3). Constant and low density antigen presentation by Siglec-H is thought to lead to an exhaustive type lessening of the response in CD4+ cells but not tolerance. A number of pathways have been proposed for the Siglec-H induced T cell hyporesponsiveness. Ever decreasing activation cycles in the presence of low level but continuous antigen delivery, as that observed with Siglec-H, have also been demonstrated to impart FoxP3+ Tregs immunosuppressive tolerogen-like effects (4, 5). Ability to identify and control Siglec-H antigen mediated delivery activities with specific antibody provides a focal point for potential development of inflammation controls.

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価格

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標識済み抗体価格

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