Anti-SIRP alpha/CD172a (15-414) [Allophycocyanin] | 抗SIRP alpha/CD172a (15-414) [Allophycocyanin]抗体 | SIRP alpha/CD172a (15-414) [Allophycocyanin] antibody

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Flow Cytometry: SIRP alpha/CD172a Antibody (15-414) [Allophycocyanin] [NBP2-00210] - Staining of normal human peripheral blood cells with Mouse IgG2a K Isotype Control APC (left) or Anti-Human CD172a (SIRP alpha) APC (right). Cells in the lymphocyte (green histogram) or granulocyte (blue histogram) gate were used for analysis.

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Background

This 15-414 monoclonal antibody reacts with human CD172a, also known as signal regulatory protein alpha (SIRP alpha). This cell surface glycoprotein consists of three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The ITIM domains have been demonstrated to recruit and bind the Src homology 2 domain-containing phosphatases SHP-1 and SHP-2. CD172a is expressed on monocytes, granulocytes, dendritic cells, and CD34+CD38- hematopoietic progenitor cells but not on T and B lymphocytes. Moreover, neurons have also been shown to express CD172. The integrin-associated protein CD47 is the extracellular ligand for CD172a. Studies show that CD172a is involved in dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis.

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価格

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標識済み抗体価格

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