抗Lgr6 [FITC]抗体 | Anti- Lgr6 [FITC] antibody
掲載日情報:2018/08/30 現在Webページ番号:59841
世界最大級の抗体製品数を取り扱うNovus Biologicals社のLgr6 [FITC]に対する抗体(anti-Lgr6 [FITC] | antibody Lgr6 [FITC])です。Novus Biologicals社の抗体は数多くの学術論文で使用実績があります。
※本製品は研究用です。研究用以外には使用できません。
PE, AlexaFluor, FITC, DyLight などの蛍光を含む、さまざまな標識体も取り扱っています。
追加しました。
Background
Relaxin family peptides which closely resembles insulin, act on a group of G-protein-coupled receptors now known as relaxin family peptide (RXFP) receptors. The leucine-rich repeat containing RXFP1 and RXFP2 and the small peptide-like RXFP3 and RXFP4 are the physiological targets for relaxin, insulin-like (INSL) peptide 3, relaxin-3 and INSL5, respectively. Leucine rich repeat containing GPCR (Lgr6) is a member of the same large family of GPCR (Lgr1-Lgr16) that binds to variety of glycoprotein hormones like TSH, FSH, LH (1). This family of receptor is unique in having a large ectodomain important for ligand binding. The large extracelluar domain binds the ligands with high affinity; there also exist a low affinity binding site in the exoloop of the trnasmembrane region. LGR6 has a subgroup-specific hinge region after leucine-rich repeats whereas LGR7, like snail LGR, contains a low density lipoprotein (LDL) receptor cysteine-rich motif at the N terminus. The expression of LGR5 is induced in the limb, tail, and intestine by T3 during metamorphosis of frog form larval stage. More importantly, LGR5 mRNA is localized to the developing adult epithelial stem cells of the intestine (2). Lgr6 are also involved in transcription silencing of CpG islands by hypermethylation in colorectal cancer which are referred as methylator phenotypes. The CAN genes include SYNE1, STRAD8, CD109, RNF, RET, APC2 MMP2, PTPRD and Lgr6 (3). Lgr5 is a marker for cycling stem cells in intestine (4) whereas Lgr6 is expressed in earliest embryonic hair placodes (5).Lgr6 positive cells are also involved in wound healing. In adult hair follicles the Lgr6 resides in a region just above the follicle bulge, this region was previously uncharacterized and does not express any known bulge stem cell markers. The Lgr6 is a marker for a distinct population of stem cells that give rise to all lineages of the skin. Unlike Lgr5, the Lgr6 is not regulated by Wnt signaling. The Lgr6-selective antibodies were generated against antigenic peptide taken from human Lgr6 protein corresponding near to carboxy terminal Lgr6 protein. Lgr6-antibodies are affinity purified over immobilized antigen based chromatography, and the purified immunoglobulins are stabilized in antibody stabilization buffer.追加しました。
価格
[在庫・価格 :2024年05月30日 00時00分現在]
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Anti-Lgr6, Rabbit-Poly, FITC |
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[在庫・価格 :2024年05月30日 00時00分現在]
Anti-Lgr6, Rabbit-Poly, FITC
文献数: 0
- 商品コード:NBP1-49696
- メーカー:NOV
- 包装:50μg
- 価格:¥103,000
- 在庫:無(未発注)
- 納期:3~4週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 |
Keywords:FLJ14471|gonadotropin receptor|GPCR|leucine-rich repeat containing G protein-coupled receptor 6|leucine-rich repeat-containing G protein-coupled receptor 6|leucine-rich repeat-containing G-protein coupled receptor 6|VTS20631 Genbank No: 59352 Protein Accession No: Q9HBX8 |
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保存条件 | 法規備考 | ||
抗原種 | 免疫動物 | Rabbit | |
交差性 | Human/Mouse/Rat | 適用 | Western Blot,ELISA |
標識 | FITC | 性状 | Antigen Affinity Purified |
吸収処理 | クラス | IgG | |
クロナリティ | Polyclonal | フォーマット | |
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