Anti-TLR2 (TL2.1) [FITC] | 抗TLR2 (TL2.1) [FITC]抗体 | TLR2 (TL2.1) [FITC] antibody

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	Flow Cytometry: TLR2 Antibody (TL2.1) [FITC] [NB100-56058] - Surface staining of stable HEK293/hTLR2 cells (IML-202, red) and vector control cells (IML-200, green) using TLR2 antibody at 1 ug/10^6 cells.
	Flow Cytometry: TLR2 Antibody (TL2.1) [FITC] [NB100-56058] - Cell surface analysis of TLR2 in 10^6 PBMCs (lymphocyte-gated) using 2 ugs ofMouse IgG2a Kappa, and red represents TLR2 antibody.
	Flow Cytometry: TLR2 Antibody (TL2.1) [FITC] [NB100-56058] - Cell surface analysis of TLR2 in 10^6 ThP1 cells using 2 ug of this antibody. The closed histogram represents cells alone, green represents isotype control, red represents anti-TLR2 antibody.

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Background

The Toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. TLR2 is differentially expressed in human cells. TLR2 is expressed in tonsils, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes expressed the highest level of TLR2 followed by CD15+ granulocytes, and CD19+ B-cells, CD3+ T-cells, and CD56+ NK cells did not express TLR2. The expression of TLR2 in different cell types is regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.

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