Anti-TLR4 (76B357.1) [FITC] | 抗TLR4 (76B357.1) [FITC]抗体 | TLR4 (76B357.1) [FITC] antibody

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Flow Cytometry: TLR4 Antibody (76B357.1) [FITC] [NB100-55951] - TLR4 expression on monocytes from human peripheral blood: PBMC were stained, in a 2 color flow test, with CD14 PE and 1 ug of either isotype control (Left, ) or TLR4-FITC (Right, this antibody. PPI negative, CD14+ cells were gated for analysis.

Flow Cytometry: TLR4 Antibody (76B357.1) [FITC] [NB100-55951] - Analysis of cell surface TLR4 in human monocyte-derived dendritic cells using this antibody at 1:200 (2.5 ug). Black and green open histograms represent unstained cells and negative control (anti-human CD14 FITC, respectively. Blue open histogram is NB100-55951 anti-TLR4 stained Dendritic cells. Data courtesy Anna Manlapat, National Institutes of Health.

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Background

The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). Among this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling (4,5). The TLR4 cDNA codes for a protein consisting of 799 amino acids with approximate molecular weight of 88 kDa (6).

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