Anti-α-Galactosyl Antibodyを測定するキット Anti-α-Galactosyl Antibody Human ELISA Kit

In human serum, natural anti-α-galactosyl antibodies (anti-α-Gal) constitute approximately 4-8 % of total serum IgM, approx. 1-2 % of total serum IgG, and they can also be found as the IgA isotope in serum, saliva, milk, colostrum and vaginal washings. About 1 % of circulating B lymphocytes in adults is capable of producing these antibodies. Their production is thought to be induced postnatally after antigenic stimuli by intestinal microflora. The biological roles of natural antibodies are thought to be protection against infectious agents, particularly at the mucosal surface, effector functions of the immune system, e.g. in removing senescent or otherwise altered cells and physiologically degraded molecules, and regulation of immune responses, particularly autoimmune responses. Moreover, the presence of anti-α-galactosyl antibodies in humans represents an important obstacle to xenotransplan-tations of porcine grafts since these antibodies participate in their rejection. Natural antibodies also play an important role in malignant processes, and they have potential to be used in treatment of tumors that express these (α-Gal) antigens (e.g. breast cancer).