Lipoxin A4 MaxSpec Standard | CAS:89663-86-5

• 価格
• 製品情報
• 製品詳細
• 文献

価格

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製品情報

Lipoxin A₄ (LXA₄) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes. LXA₄ is equipotent to leukotriene B₄ (LTB₄; Item Nos. 10007240 | 20110) in inducing superoxide generation in human neutrophils at 0.1 µM. LXA₄ is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.

LXA₄ MaxSpec^® standard is a quantitative grade standard of LXA₄ (Item No. 90410) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This LXA₄ MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

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製品詳細

name	Lipoxin A4 MaxSpec Standard
Formal Name	5S,6R,15S-trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid
CAS Number	89663-86-5
Synonyms	LXA4 5(S),6(R),15(S)-TriHETE
Molecular Formula	C20H32O5
Formula Weight	352.5
Purity	≥95%
Formulation	A solution in ethanol
SMILES	CCCCC[C@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)CCCC(O)=O
InChI Code	InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1
InChI Key	IXAQOQZEOGMIQS-SSQFXEBMSA-N
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere
Stability	≥ 1 year

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文献

1. Serhan, C.N., Nicolaou, K.C., Webber, S.E., et al. Lipoxin A. Stereochemistry and biosynthesis. J. Biol. Chem. 261(35), 16340-16345 (1986).

2. Serhan, C.N., Hamberg, M., and Samuelsson, B. Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes. Proc. Natl. Acad. Sci. U.S.A. 81(17), 5335-5339 (1984).

3. Ramstedt, U., Serhan, C.N., Nicolaou, K.C., et al. Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: Studies on stereospecificity of inhibition and mode of action. J. Immunol. 138(1), 266-270 (1987).

4. Maddox, J.F., and Serhan, C.N. Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: Selective inactivation by dehydrogenation and reduction. J. Exp. Med. 183(1), 137-146 (1996).

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